5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE

Synonym(s):5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride

CAS NO.：137206-97-4
Empirical Formula: C16H14N2O2
Molecular Weight: 266.29
MDL number: MFCD02262123
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Structural

What is 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE?

Description

DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.

The Uses of 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE

DMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ).

What are the applications of Application

DMPQ dihydrochloride is a potent and selective inhibitor of PDGFRβ tyrosine kinase

Biological Activity

A potent and selective inhibitor of human vascular β -type platelet derived growth factor receptor tyrosine kinase (PDGFR β ) (IC 50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

References

1) Dolle et al. (1994), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; J. Med. Chem., 37 2627

Properties of 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE

Boiling point:	441.3±40.0 °C(Predicted)
Density	1.192±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 30 mg/ml).
form	solid
pka	3.58±0.38(Predicted)
color	Yellow
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.