5,6-Dichloronicotinic acid

Synonym(s):5,6-Dichloronicotinic acid;5,6-Dichloropyridine-3-carboxylic acid

CAS NO.：41667-95-2
Empirical Formula: C6H3Cl2NO2
Molecular Weight: 192
MDL number: MFCD00075181
EINECS: 609-951-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-16 10:38:37

What is 5,6-Dichloronicotinic acid?

Chemical properties

white to off-white crystalline powder

The Uses of 5,6-Dichloronicotinic acid

5,6-Dichloronicotinic acid is a dihalonicotinic acid. It is used in the preparation of 5-chloro-6-iodonicotinic acid by iodine displacement.

What are the applications of Application

5,6-Dichloronicotinic acid is a compound that can be synthesized by reacting methyl ketones with chloroacetic acid. It is used in the synthesis of maleic anhydride and has been shown to inhibit the catalysis of acetylcholine chloride. It has also been shown to have an inhibitory effect on Alzheimer's disease. The kinetic mechanism for this inhibition occurs through the hydrolysis step of 5,6-Dichloronicotinic acid by magnesium chloride in hexane solution. The reactive acylation reaction proceeds when it reacts with acetic anhydride in the presence of pyridine.

Properties of 5,6-Dichloronicotinic acid

Melting point:	164-168 °C(lit.)
Boiling point:	342.1±37.0 °C(Predicted)
Density	1.612±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Powder
pka	2.87±0.10(Predicted)
color	White to beige to tan
BRN	383740
InChI	InChI=1S/C6H3Cl2NO2/c7-4-1-3(6(10)11)2-9-5(4)8/h1-2H,(H,10,11)
CAS DataBase Reference	41667-95-2(CAS DataBase Reference)