5-Nitrosalicylic acid

Synonym(s):2-Hydroxy-5-nitrobenzoic acid;5-Nitrosalicylic acid;5-Nitrosalicylic acid, 5-Nitro-2-hydroxybenzoic acid;Anilotic acid

CAS NO.：96-97-9
Empirical Formula: C7H5NO5
Molecular Weight: 183.12
MDL number: MFCD00007338
EINECS: 202-548-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-15 19:00:21

What is 5-Nitrosalicylic acid?

Chemical properties

yellow powder

The Uses of 5-Nitrosalicylic acid

5-Nitrosalicylic Acid is a salicylic acid derivative with anti-inflammatory effect against colitis.

Definition

ChEBI: A monohydroxybenzoic acid in which the hydroxy group is ortho- to the carboxylic acid group and which has a nitro substituent para- to the phenolic hydroxy group.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 2377, 1995 DOI: 10.1016/0040-4039(95)00281-G

General Description

2-Hydroxy-5-nitrobenzoic acid inhibits the activity of wild type-bovine low M_rprotein tyrosine phosphatase. The inhibition constant has been evaluated.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise the acid from Me2CO (charcoal), then twice more from Me2CO alone, aqueous EtOH (m 234-236o) or H2O (m 232-233o). [Beilstein 10 III 197, 10 IV 255.]

Properties of 5-Nitrosalicylic acid

Melting point:	228-230 °C(lit.)
Boiling point:	316.77°C (rough estimate)
Density	1,65 g/cm³
vapor pressure	0Pa at 25℃
refractive index	1.6280 (estimate)
storage temp.	no restrictions.
solubility	water: soluble1g in 1475ml(lit.)
pka	pK1:2.12 (25°C)
form	Liquid
color	Clear yellow-beige to orange-brown
Water Solubility	Soluble in water 1g/1475ml .
Merck	14,6631
BRN	2213719
CAS DataBase Reference	96-97-9(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 2-hydroxy-5-nitro- (96-97-9)

Safety information for 5-Nitrosalicylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.