5-Nitrosalicylic acid
Synonym(s):2-Hydroxy-5-nitrobenzoic acid;5-Nitrosalicylic acid;5-Nitrosalicylic acid, 5-Nitro-2-hydroxybenzoic acid;Anilotic acid
- CAS NO.：96-97-9
- Empirical Formula: C7H5NO5
- Molecular Weight: 183.12
- MDL number: MFCD00007338
- EINECS: 202-548-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is 5-Nitrosalicylic acid?
Chemical properties
yellow powder
The Uses of 5-Nitrosalicylic acid
5-Nitrosalicylic Acid is a salicylic acid derivative with anti-inflammatory effect against colitis.
Definition
ChEBI: A monohydroxybenzoic acid in which the hydroxy group is ortho- to the carboxylic acid group and which has a nitro substituent para- to the phenolic hydroxy group.
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 2377, 1995 DOI: 10.1016/0040-4039(95)00281-G
General Description
2-Hydroxy-5-nitrobenzoic acid inhibits the activity of wild type-bovine low Mr protein tyrosine phosphatase. The inhibition constant has been evaluated.
Flammability and Explosibility
Non flammable
Purification Methods
Crystallise the acid from Me2CO (charcoal), then twice more from Me2CO alone, aqueous EtOH (m 234-236o) or H2O (m 232-233o). [Beilstein 10 III 197, 10 IV 255.]
Properties of 5-Nitrosalicylic acid
| Melting point: | 228-230 °C(lit.) |
| Boiling point: | 316.77°C (rough estimate) |
| Density | 1,65 g/cm3 |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.6280 (estimate) |
| storage temp. | no restrictions. |
| solubility | water: soluble1g in 1475ml(lit.) |
| pka | pK1:2.12 (25°C) |
| form | Liquid |
| color | Clear yellow-beige to orange-brown |
| Water Solubility | Soluble in water 1g/1475ml . |
| Merck | 14,6631 |
| BRN | 2213719 |
| CAS DataBase Reference | 96-97-9(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 2-hydroxy-5-nitro- (96-97-9) |
Safety information for 5-Nitrosalicylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 5-Nitrosalicylic acid
| InChIKey | PPDRLQLKHRZIJC-UHFFFAOYSA-N |
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