2-Chloro-5-nitrobenzoic acid

Synonym(s):2-Chloro-5-nitrobenzoic acid

CAS NO.：2516-96-3
Empirical Formula: C7H4ClNO4
Molecular Weight: 201.56
MDL number: MFCD00007294
EINECS: 219-739-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 2-Chloro-5-nitrobenzoic acid?

Chemical properties

light yellow to light yellow-green crystalline

The Uses of 2-Chloro-5-nitrobenzoic acid

2-Chloro-5-nitrobenzoic Acid is used in the synthesis of sesquiterpenoids as potential antibacterial compounds. Also used in the synthesis of substituted phenyl oxazoles as novel LSD1 inhibitors with antiproliferative activity. In addition it’s used to synthesize cathespin L inhibitors.

General Description

2-Chloro-5-nitrobenzoic acid undergoes microwave-assisted, regioselective amination reaction with aliphatic and aromatic amines to yield N-substituted 5-nitroanthranilic acid derivatives. It acts as ligand and forms a red luminescent one dimensional coordination polymer with Eu(III).

Properties of 2-Chloro-5-nitrobenzoic acid

Melting point:	165-168 °C (lit.)
Boiling point:	356.5±27.0 °C(Predicted)
Density	1.6
refractive index	1.6000 (estimate)
Flash point:	>100°C
storage temp.	Sealed in dry,Room Temperature
solubility	3.6g/l
form	Crystalline Powder
pka	pK1: 2.17 (25°C)
color	Light yellow to beige-brown
BRN	1877474
CAS DataBase Reference	2516-96-3(CAS DataBase Reference)
NIST Chemistry Reference	2-Chloro-5-nitrobenzoic acid(2516-96-3)
EPA Substance Registry System	Benzoic acid, 2-chloro-5-nitro- (2516-96-3)

Safety information for 2-Chloro-5-nitrobenzoic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H317:Sensitisation, Skin H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.