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HomeProduct name list5-Nitro-1,10-phenanthroline

5-Nitro-1,10-phenanthroline

Synonym(s):Nitroferroin

  • CAS NO.:4199-88-6
  • Empirical Formula: C12H7N3O2
  • Molecular Weight: 225.2
  • MDL number: MFCD00004981
  • EINECS: 224-097-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-26 21:25:48
5-Nitro-1,10-phenanthroline Structural

What is 5-Nitro-1,10-phenanthroline?

Chemical properties

Light yellow to yellow-brown crystalline powder

The Uses of 5-Nitro-1,10-phenanthroline

5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline.

Biochem/physiol Actions

Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity.

Purification Methods

Crystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.]

Properties of 5-Nitro-1,10-phenanthroline

Melting point: 202-204 °C(lit.)
Boiling point: 366.71°C (rough estimate)
Density  1.2844 (rough estimate)
refractive index  1.5700 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  soluble in Alcohol,Benzene
form  crystalline
pka pK1:3.232(+1) (25°C)
color  yellow to orange
Water Solubility  insoluble
BRN  196245
CAS DataBase Reference 4199-88-6(CAS DataBase Reference)
EPA Substance Registry System 1,10-Phenanthroline, 5-nitro- (4199-88-6)

Safety information for 5-Nitro-1,10-phenanthroline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Nitro-1,10-phenanthroline

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