5-Nitro-1,10-phenanthroline
Synonym(s):Nitroferroin
- CAS NO.:4199-88-6
- Empirical Formula: C12H7N3O2
- Molecular Weight: 225.2
- MDL number: MFCD00004981
- EINECS: 224-097-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-26 21:25:48
What is 5-Nitro-1,10-phenanthroline?
Chemical properties
Light yellow to yellow-brown crystalline powder
The Uses of 5-Nitro-1,10-phenanthroline
5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline.
Biochem/physiol Actions
Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity.
Purification Methods
Crystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.]
Properties of 5-Nitro-1,10-phenanthroline
Melting point: | 202-204 °C(lit.) |
Boiling point: | 366.71°C (rough estimate) |
Density | 1.2844 (rough estimate) |
refractive index | 1.5700 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | soluble in Alcohol,Benzene |
form | crystalline |
pka | pK1:3.232(+1) (25°C) |
color | yellow to orange |
Water Solubility | insoluble |
BRN | 196245 |
CAS DataBase Reference | 4199-88-6(CAS DataBase Reference) |
EPA Substance Registry System | 1,10-Phenanthroline, 5-nitro- (4199-88-6) |
Safety information for 5-Nitro-1,10-phenanthroline
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Nitro-1,10-phenanthroline
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