5-Methylisatin

Synonym(s):5-Methylindole-2,3-dione;NSC 9398

CAS NO.：608-05-9
Empirical Formula: C9H7NO2
Molecular Weight: 161.16
MDL number: MFCD00005721
EINECS: 210-152-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is 5-Methylisatin?

Chemical properties

Red to brown powder or crystals

The Uses of 5-Methylisatin

Reactant for preparation of:• ;Antimycobacterial agents1• ;Promoters of central nervous system (CNS) depression in mice2• ;Inhibitors of TAK1 kinase3• ;Anti-human immunodeficiency virus (HIV) agent4• ;Potent herpes simplex virus (HSV) inhibitors5• ;Antimicrobial agents6• ;IKKβ inhibitors7• ;Potential drug to combat human immunodeficiency virus-tuberculosis (HIV-TB) coinfection8• ;Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors9• ;Antibacterial and anticancer agents

The Uses of 5-Methylisatin

Reactant for preparation of:

Antimycobacterial agents
Promoters of central nervous system (CNS) depression in mice
Inhibitors of TAK1 kinase
Anti-human immunodeficiency virus (HIV) agent
Potent herpes simplex virus (HSV) inhibitors
Antimicrobial agents
IKKβ inhibitors
Potential drug to combat human immunodeficiency virus-tuberculosis (HIV-TB) coinfection
Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors
Antibacterial and anticancer agents

General Description

5-Methylisatin is an inhibitor of atrial natriuretic peptide (ANP) receptor coupled with guanylyl cyclase (GC).

Properties of 5-Methylisatin

Melting point:	180 °C (dec.) (lit.)
Density	1.301±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	methanol: soluble25mg/mL, clear to slightly hazy, orange to red
form	crystalline
pka	10.42±0.20(Predicted)
color	orange
BRN	123738
CAS DataBase Reference	608-05-9(CAS DataBase Reference)
NIST Chemistry Reference	5-Methyl-2,3-indolinedione(608-05-9)

Safety information for 5-Methylisatin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.