5-Methylindole
Synonym(s):NSC 522562
- CAS NO.：614-96-0
- Empirical Formula: C9H9N
- Molecular Weight: 131.17
- MDL number: MFCD00005680
- EINECS: 210-400-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-11-20 17:40:16
What is 5-Methylindole?
Chemical properties
white to slightly beige crystalline solid
The Uses of 5-Methylindole
5-Methylindole is used in the synthesis of novel protein kinase inhibitors.
The Uses of 5-Methylindole
5-Methylindole is used as reactant for preparation of pharmaceutically active 2-oxo-1-pyrrolidine analogues, potential anticancer immunomodulators, IL2-inducible T-cell kinase (ITK) inhibitors and CRTh2 antagonists.
What are the applications of Application
5-Methylindole is 5-Methylindole is a reactant for preparation of sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors, IL2-inducible T-cell kinase (ITK) inhibitors.
Synthesis Reference(s)
Synthesis, p. 1036, 1982 DOI: 10.1055/s-1982-30054
General Description
The binding of 5-methylindole (inducer) to the Escherichia coli trp repressor has been studied. The mass analyzed threshold ionization spectra of jetcooled 5-methylindole (5MI) has also been studied.
Properties of 5-Methylindole
| Melting point: | 60-62 °C (lit.) |
| Boiling point: | 100°C/3mm |
| Density | 1.0202 |
| refractive index | 1.6070 (estimate) |
| Flash point: | 100°C/3mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 17.17±0.30(Predicted) |
| form | Crystalline Solid |
| color | White to slightly beige |
| Water Solubility | Insoluble in water. |
| Sensitive | Light Sensitive |
| BRN | 2228 |
| CAS DataBase Reference | 614-96-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Indole, 5-methyl-(614-96-0) |
| EPA Substance Registry System | 5-Methylindole (614-96-0) |
Safety information for 5-Methylindole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Methylindole
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