5-Methylindole

Synonym(s):NSC 522562

CAS NO.：614-96-0
Empirical Formula: C9H9N
Molecular Weight: 131.17
MDL number: MFCD00005680
EINECS: 210-400-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:22

What is 5-Methylindole?

Chemical properties

white to slightly beige crystalline solid

The Uses of 5-Methylindole

5-Methylindole is used in the synthesis of novel protein kinase inhibitors.

The Uses of 5-Methylindole

5-Methylindole is used as reactant for preparation of pharmaceutically active 2-oxo-1-pyrrolidine analogues, potential anticancer immunomodulators, IL2-inducible T-cell kinase (ITK) inhibitors and CRTh2 antagonists.

What are the applications of Application

5-Methylindole is 5-Methylindole is a reactant for preparation of sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors, IL2-inducible T-cell kinase (ITK) inhibitors.

Synthesis Reference(s)

Synthesis, p. 1036, 1982 DOI: 10.1055/s-1982-30054

General Description

The binding of 5-methylindole (inducer) to the Escherichia coli trp repressor has been studied. The mass analyzed threshold ionization spectra of jetcooled 5-methylindole (5MI) has also been studied.

Properties of 5-Methylindole

Melting point:	60-62 °C (lit.)
Boiling point:	100°C/3mm
Density	1.0202
refractive index	1.6070 (estimate)
Flash point:	100°C/3mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	17.17±0.30(Predicted)
form	Crystalline Solid
color	White to slightly beige
Water Solubility	Insoluble in water.
Sensitive	Light Sensitive
BRN	2228
CAS DataBase Reference	614-96-0(CAS DataBase Reference)
NIST Chemistry Reference	1H-Indole, 5-methyl-(614-96-0)
EPA Substance Registry System	5-Methylindole (614-96-0)

Safety information for 5-Methylindole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.