5-Indolylboronic acid
Synonym(s):5-Indoleboronic acid;Indole-5-boronic acid
- CAS NO.：144104-59-6
- Empirical Formula: C8H8BNO2
- Molecular Weight: 160.97
- MDL number: MFCD01319013
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 5-Indolylboronic acid?
Chemical properties
White to light yellow crystal powde
The Uses of 5-Indolylboronic acid
Indole-5-boronic acid is a useful reagent for palladium and copper catalyzed oxidative cross-coupling of mercaptoacetylenes and arylboronic acids. A reagent used in the synthesis of other biologically active molecules.
The Uses of 5-Indolylboronic acid
Reactant involved in the synthesis of biologically active molecules including:
- Indole inhibitors of MMP-13 for arthritic disease treatment
- Substituted pyrimidines acting as tubulin polymerization inhibitors
Reactant involved in Suzuki coupling reactions for synthesis of
- Aryl- hetarylfurocoumarins
- Aryl-substituted oxabenzindoles and methanobenzindoles
Reactant involved in:
- Oxidative cross-coupling with mercaptoacetylenes
- Trifluoromethylation
General Description
May contain varying amounts of anhydride
Properties of 5-Indolylboronic acid
| Melting point: | 170-175 °C |
| Boiling point: | 433.2±37.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Crystalline Powder |
| pka | 8.91±0.30(Predicted) |
| color | White |
| Sensitive | Air Sensitive |
| CAS DataBase Reference | 144104-59-6(CAS DataBase Reference) |
Safety information for 5-Indolylboronic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Indolylboronic acid
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