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HomeProduct name list5-HYDROXYTRYPTOPHOL

5-HYDROXYTRYPTOPHOL

  • CAS NO.:154-02-9
  • Empirical Formula: C10H11NO2
  • Molecular Weight: 177.2
  • MDL number: MFCD00047197
  • EINECS: 205-820-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
5-HYDROXYTRYPTOPHOL Structural

What is 5-HYDROXYTRYPTOPHOL?

Chemical properties

Off-White Crystalline Powder

The Uses of 5-HYDROXYTRYPTOPHOL

A metabolite of Tryptophan (T947200).

What are the applications of Application

5-Hydroxy Tryptophol is a metabolite of tryptophan

Definition

ChEBI: 5-Hydroxytryptophol is a member of indoles.

Hazard

A reproductive hazard.

Biological Activity

5-hydroxy tryptophol is a metabolite of tryptophan.tryptophan (encoded by the codon ugg) is an α-amino acid that is used in the biosynthesis of proteins. tryptophan has an α-amino group, an α-carboxylic acid group, and a side chain indole, demonstrating it as a non-polar, aromatic amino acid. tryptophan is critical in humans, but the body cannot synthesize it and therefore tryptophan must be obtained from the diet. tryptophan is also found to be a precursor to the neurotransmitters serotonin and melatonin.

in vitro

in previous studies, 5-hydroxy tryptophol was identified as a metabolite of tryptophan that was formed by the alcohol dehydrogenase-catalyzed reduction of the serotonin intermediate, 5-hydroxyindoleacetaldehyde. moreover, depending on the tissue nad/nadh ratio, the acetaldehyde intermediate could also be oxidized by aldehyde dehydrogenase to form 5-hydroxyindoleacetic acid. therefore, the ratio of 5-hydroxy tryptophol to 5-hydroxyindoleacetic acid could be used as a biomarker for recent alcohol consumption [1,2].

References

[1] yokoyama, m. t. and carlson, j.r. dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro. appl.microbiol. 27(3), 540-548 (1974).
[2] beck, o. ,stephanson, n.,btthcer, m., et al. biomarkers to disclose recent intake of alcohol: potential of 5-hydroxytryptophol glucuronide testing using new direct uplc-tandem ms and elisa methods. alcohol & alcoholism 42(4), 321-325 (2007).

Properties of 5-HYDROXYTRYPTOPHOL

Melting point: 111-113°
Boiling point: 435.2±30.0 °C(Predicted)
Density  1.356±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 10.07±0.40(Predicted)
color  White to Light Red

Safety information for 5-HYDROXYTRYPTOPHOL

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-HYDROXYTRYPTOPHOL

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