5-HYDROXYTRYPTOPHOL
- CAS NO.:154-02-9
- Empirical Formula: C10H11NO2
- Molecular Weight: 177.2
- MDL number: MFCD00047197
- EINECS: 205-820-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is 5-HYDROXYTRYPTOPHOL?
Chemical properties
Off-White Crystalline Powder
The Uses of 5-HYDROXYTRYPTOPHOL
A metabolite of Tryptophan (T947200).
What are the applications of Application
5-Hydroxy Tryptophol is a metabolite of tryptophan
Definition
ChEBI: 5-Hydroxytryptophol is a member of indoles.
Hazard
A reproductive hazard.
Biological Activity
5-hydroxy tryptophol is a metabolite of tryptophan.tryptophan (encoded by the codon ugg) is an α-amino acid that is used in the biosynthesis of proteins. tryptophan has an α-amino group, an α-carboxylic acid group, and a side chain indole, demonstrating it as a non-polar, aromatic amino acid. tryptophan is critical in humans, but the body cannot synthesize it and therefore tryptophan must be obtained from the diet. tryptophan is also found to be a precursor to the neurotransmitters serotonin and melatonin.
in vitro
in previous studies, 5-hydroxy tryptophol was identified as a metabolite of tryptophan that was formed by the alcohol dehydrogenase-catalyzed reduction of the serotonin intermediate, 5-hydroxyindoleacetaldehyde. moreover, depending on the tissue nad/nadh ratio, the acetaldehyde intermediate could also be oxidized by aldehyde dehydrogenase to form 5-hydroxyindoleacetic acid. therefore, the ratio of 5-hydroxy tryptophol to 5-hydroxyindoleacetic acid could be used as a biomarker for recent alcohol consumption [1,2].
References
[1] yokoyama, m. t. and carlson, j.r. dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro. appl.microbiol. 27(3), 540-548 (1974).
[2] beck, o. ,stephanson, n.,btthcer, m., et al. biomarkers to disclose recent intake of alcohol: potential of 5-hydroxytryptophol glucuronide testing using new direct uplc-tandem ms and elisa methods. alcohol & alcoholism 42(4), 321-325 (2007).
Properties of 5-HYDROXYTRYPTOPHOL
Melting point: | 111-113° |
Boiling point: | 435.2±30.0 °C(Predicted) |
Density | 1.356±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 10.07±0.40(Predicted) |
color | White to Light Red |
Safety information for 5-HYDROXYTRYPTOPHOL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-HYDROXYTRYPTOPHOL
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