5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
Synonym(s):N-Des(4-chlorobenzoyl)indomethacin;2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetic acid;5-Methoxy-2-methyl-3-indoleacetic acid;NSC 97026
- CAS NO.：2882-15-7
- Empirical Formula: C12H13NO3
- Molecular Weight: 219.24
- MDL number: MFCD00005618
- EINECS: 220-734-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID?
Chemical properties
slightly yellow fine crystalline powder
The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
5-Methoxy-2-methyl-3-indoleacetic acid was used for quantitative determination of indomethacin and its major impurities in suppository and capsule formulations by HPLC. 5-Methoxy-2-methyl-3-indoleacetic acid was used in a study to develop fast, sensitive and simultaneous determination of metabolites of serotonin using liquid chromatography with mass spectrometric detection.
The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
A metabolite of Indomethacin.
The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
- Reactant for preparation of antimalarial agents
- Reactant for preparation of ndomethacin analogs as cyclooxygenase and lipoxygenase inhibitors with antiinflammatory activity
- Reactant for preparation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents
- Reactant for preparation of histone deacetylase inhibitors
- Reactant for preparation of 2,N6,5′-substituted adenosine derivatives as ligands for A2B adenosine receptor
- Reactant for preparation of prostaglandin D2 receptor antagonist
Definition
ChEBI: N-Deschlorobenzoyl indomethacin is a member of indole-3-acetic acids.
General Description
5-Methoxy-2-methyl-3-indoleacetic acid is hydrolysis product of indomethacin.
Properties of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
| Melting point: | 161-163 °C (lit.) |
| Boiling point: | 360.05°C (rough estimate) |
| Density | 1.1825 (rough estimate) |
| refractive index | 1.5270 (estimate) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble |
| pka | 4.22±0.30(Predicted) |
| form | Crystalline Powder |
| color | Off-white to light yellow or light beige |
| CAS DataBase Reference | 2882-15-7(CAS DataBase Reference) |
Safety information for 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
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