5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
Synonym(s):N-Des(4-chlorobenzoyl)indomethacin;2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetic acid;5-Methoxy-2-methyl-3-indoleacetic acid;NSC 97026
- CAS NO.：2882-15-7
- Empirical Formula: C12H13NO3
- Molecular Weight: 219.24
- MDL number: MFCD00005618
- EINECS: 220-734-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID?
Chemical properties
slightly yellow fine crystalline powder
The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
5-Methoxy-2-methyl-3-indoleacetic acid was used for quantitative determination of indomethacin and its major impurities in suppository and capsule formulations by HPLC. 5-Methoxy-2-methyl-3-indoleacetic acid was used in a study to develop fast, sensitive and simultaneous determination of metabolites of serotonin using liquid chromatography with mass spectrometric detection.
The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
A metabolite of Indomethacin.
The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
- Reactant for preparation of antimalarial agents
- Reactant for preparation of ndomethacin analogs as cyclooxygenase and lipoxygenase inhibitors with antiinflammatory activity
- Reactant for preparation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents
- Reactant for preparation of histone deacetylase inhibitors
- Reactant for preparation of 2,N6,5′-substituted adenosine derivatives as ligands for A2B adenosine receptor
- Reactant for preparation of prostaglandin D2 receptor antagonist
Definition
ChEBI: N-Deschlorobenzoyl indomethacin is a member of indole-3-acetic acids.
General Description
5-Methoxy-2-methyl-3-indoleacetic acid is hydrolysis product of indomethacin.
Properties of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
| Melting point: | 161-163 °C (lit.) |
| Boiling point: | 360.05°C (rough estimate) |
| Density | 1.1825 (rough estimate) |
| refractive index | 1.5270 (estimate) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble |
| pka | 4.22±0.30(Predicted) |
| form | Crystalline Powder |
| color | Off-white to light yellow or light beige |
| CAS DataBase Reference | 2882-15-7(CAS DataBase Reference) |
Safety information for 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
New Products
Tubulysin C Tubulysin I 2,2-diethoxyethanethioamide (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Potassium HMDS (1.0 M in THF) CYCLOBUTYLAMINE HYDROCHLORIDE 4-(Benzyloxy)-3-bromophenylacetic Acid 2H-Pyran, 4-ethynyltetrahydro- 4,4-DIFLUOROPIPERIDINE 1-(1,1-Difluoroethyl)-2-fluorobenzene 3-Aminocyclobutanone hydrochloride (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Fuel shell Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
You may like
-
5-Methoxy-2-methyl-3-indoleacetic acid CAS 2882-15-7View Details
2882-15-7 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.