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HomeProduct name list5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

Synonym(s):N-Des(4-chlorobenzoyl)indomethacin;2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetic acid;5-Methoxy-2-methyl-3-indoleacetic acid;NSC 97026

  • CAS NO.:2882-15-7
  • Empirical Formula: C12H13NO3
  • Molecular Weight: 219.24
  • MDL number: MFCD00005618
  • EINECS: 220-734-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:37
5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Structural

What is 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID?

Chemical properties

slightly yellow fine crystalline powder

The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

5-Methoxy-2-methyl-3-indoleacetic acid was used for quantitative determination of indomethacin and its major impurities in suppository and capsule formulations by HPLC. 5-Methoxy-2-methyl-3-indoleacetic acid was used in a study to develop fast, sensitive and simultaneous determination of metabolites of serotonin using liquid chromatography with mass spectrometric detection.

The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

A metabolite of Indomethacin.

The Uses of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

  • Reactant for preparation of antimalarial agents
  • Reactant for preparation of ndomethacin analogs as cyclooxygenase and lipoxygenase inhibitors with antiinflammatory activity
  • Reactant for preparation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents
  • Reactant for preparation of histone deacetylase inhibitors
  • Reactant for preparation of 2,N6,5′-substituted adenosine derivatives as ligands for A2B adenosine receptor
  • Reactant for preparation of prostaglandin D2 receptor antagonist

Definition

ChEBI: N-Deschlorobenzoyl indomethacin is a member of indole-3-acetic acids.

General Description

5-Methoxy-2-methyl-3-indoleacetic acid is hydrolysis product of indomethacin.

Properties of 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

Melting point: 161-163 °C (lit.)
Boiling point: 360.05°C (rough estimate)
Density  1.1825 (rough estimate)
refractive index  1.5270 (estimate)
storage temp.  2-8°C
solubility  methanol: soluble
pka 4.22±0.30(Predicted)
form  Crystalline Powder
color  Off-white to light yellow or light beige
CAS DataBase Reference 2882-15-7(CAS DataBase Reference)

Safety information for 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID

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