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HomeProduct name list5-Hydroxyadamantan-2-one

5-Hydroxyadamantan-2-one

  • CAS NO.:20098-14-0
  • Empirical Formula: C10H14O2
  • Molecular Weight: 166.22
  • MDL number: MFCD00192211
  • EINECS: 1533716-785-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 17:10:30
5-Hydroxyadamantan-2-one Structural

What is 5-Hydroxyadamantan-2-one?

Description

5-Hydroxy-2-adamantanone (5-hydroxyadamantan-2-one) is a versatile starting material for synthesising various 2,5- or 1,4-disubstituted adamantanes. Chemical methods for synthesizing 5-hydroxy-2-adamantanone include disproportionation of 2-hydroxyadamantane and oxidation of 2-adamantanone. A synthetic approach to produce 5-hydroxy-2-adamantanone using P450cam (CYP101A1; a camphor monooxygenase) coupled with NADH regeneration as an oxidation biocatalyst has been reported[1].

Chemical properties

White crystal or crystalline powder

The Uses of 5-Hydroxyadamantan-2-one

anthelmintic

The Uses of 5-Hydroxyadamantan-2-one

5-Hydroxy-2-adamantanone may be used in the following studies:

  • As a model compound to investigate the application of lanthanide NMR shift reagents for the analysis of disubstituted derivative of adamantane.
  • As a starting material for the synthesis of E-2-amino-5-hydroxyadamantane.
  • As a starting material for the synthesis of 4-(triphenylsilyloxy)adamantan-1-ol.

Definition

ChEBI: Idramantone is a member of adamantanones.

brand name

INDICLOR (Nycomed Amersham).

General Description

5-Hydroxy-2-adamantanone is a disubstituted derivative of adamantane. The biocatalyzed synthesis of 5-hydroxy-2-adamantanone from 2-adamantanone has been investigated.

References

[1] Toshiki Furuya . “Biocatalytic production of 5-hydroxy-2-adamantanone by P450cam coupled with NADH regeneration.” Journal of Molecular Catalysis B-enzymatic 94 (2013): Pages 111-118.

Properties of 5-Hydroxyadamantan-2-one

Melting point: >300 °C (lit.)
Boiling point: 296.5±33.0 °C(Predicted)
Density  1.301±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO, Methanol
form  Crystalline Powder
pka 14.69±0.20(Predicted)
color  White to off-white
InChI InChI=1S/C10H14O2/c11-9-7-1-6-2-8(9)5-10(12,3-6)4-7/h6-8,12H,1-5H2
CAS DataBase Reference 20098-14-0(CAS DataBase Reference)

Safety information for 5-Hydroxyadamantan-2-one

Signal word Warning
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 5-Hydroxyadamantan-2-one

InChIKey TZBDEVBNMSLVKT-RIKBPLFRSA-N
SMILES C12CC3(O)CC(CC(C3)C1=O)C2

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