5-Fluorouridine
- CAS NO.:316-46-1
- Empirical Formula: C9H11FN2O6
- Molecular Weight: 262.19
- MDL number: MFCD00036832
- EINECS: 206-260-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 20:01:59
What is 5-Fluorouridine ?
Description
5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.
Chemical properties
White Powder
The Uses of 5-Fluorouridine
5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.
The Uses of 5-Fluorouridine
5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).
The Uses of 5-Fluorouridine
Antihypertensive
What are the applications of Application
5-Fluorouridine is a proapoptotic and cytotoxic nucleoside analog
Definition
ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.
General Description
5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.
Biochem/physiol Actions
5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
Purification Methods
5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]
References
1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297
Properties of 5-Fluorouridine
Melting point: | 182-184 °C |
alpha | 17 º (c=2, water 25 ºC) |
Density | 1.4200 (estimate) |
refractive index | 18 ° (C=1, H2O) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming) |
form | Powder |
pka | 7.63±0.10(Predicted) |
color | White |
Water Solubility | soluble |
BRN | 33662 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 316-46-1(CAS DataBase Reference) |
Safety information for 5-Fluorouridine
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H341:Germ cell mutagenicity H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 5-Fluorouridine
New Products
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