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HomeProduct name list5-Fluorouridine

5-Fluorouridine

  • CAS NO.:316-46-1
  • Empirical Formula: C9H11FN2O6
  • Molecular Weight: 262.19
  • MDL number: MFCD00036832
  • EINECS: 206-260-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
5-Fluorouridine  Structural

What is 5-Fluorouridine ?

Description

5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.

Chemical properties

White Powder

The Uses of 5-Fluorouridine

5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.

The Uses of 5-Fluorouridine

5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).

The Uses of 5-Fluorouridine

Antihypertensive

What are the applications of Application

5-Fluorouridine is a proapoptotic and cytotoxic nucleoside analog

Definition

ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.

General Description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Purification Methods

5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]

References

1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297

Properties of 5-Fluorouridine

Melting point: 182-184 °C
alpha  17 º (c=2, water 25 ºC)
Density  1.4200 (estimate)
refractive index  18 ° (C=1, H2O)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
form  Powder
pka 7.63±0.10(Predicted)
color  White
Water Solubility  soluble
BRN  33662
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference 316-46-1(CAS DataBase Reference)

Safety information for 5-Fluorouridine

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for 5-Fluorouridine

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