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HomeProduct name list5-Fluorouridine

5-Fluorouridine

  • CAS NO.:316-46-1
  • Empirical Formula: C9H11FN2O6
  • Molecular Weight: 262.19
  • MDL number: MFCD00036832
  • EINECS: 206-260-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
5-Fluorouridine  Structural

What is 5-Fluorouridine ?

Description

5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1? Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity.2 Cell permeable and active in vivo.

Chemical properties

White Powder

The Uses of 5-Fluorouridine

5-Fluoro Uridine is an active metabolite of Doxifluridine (D556750).

The Uses of 5-Fluorouridine

Antihypertensive

The Uses of 5-Fluorouridine

5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.

What are the applications of Application

5-Fluorouridine is a proapoptotic and cytotoxic nucleoside analog

Definition

ChEBI: An organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring.

General Description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Purification Methods

5Fluorouridine is recrystallised from EtOH/Et2O and dried at 100o in a vacuum. UV: max 269nm (pH 7.2, H2O), 270nm (pH 14, H2O). [Liang et al. Mol Pharmacol 21 224 1982, Beilstein 24 III/IV 1231.]

References

1) Yen et al. (2006), Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries; RNA, 12 797 2) Schmittgen et al. (2005), Diverse gene expression pattern during 5-fluorouridine-induced apoptosis; Int. J. Oncol., 27 297

Properties of 5-Fluorouridine

Melting point: 182-184 °C
alpha  17 º (c=2, water 25 ºC)
Density  1.4200 (estimate)
refractive index  18 ° (C=1, H2O)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 50 mg/ml), in Water (up to 50 mg/ml), or in Ethanol (up to 6 mg/ml with warming)
form  Powder
pka 7.63±0.10(Predicted)
color  White
Water Solubility  soluble
BRN  33662
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference 316-46-1(CAS DataBase Reference)

Safety information for 5-Fluorouridine

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for 5-Fluorouridine

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