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HomeProduct name list5-Fluoro-2-hydroxypyridine

5-Fluoro-2-hydroxypyridine

Synonym(s):5-Fluoro-2-pyridinol

5-Fluoro-2-hydroxypyridine Structural

What is 5-Fluoro-2-hydroxypyridine?

The Uses of 5-Fluoro-2-hydroxypyridine

5-Fluoro-2-hydroxypyridine is a halogenated compound used in the synthesis of 5-Fluoro-2-hydroxy-3-nitropyridine and 5-halogenated pyrimidine compounds.

Synthesis

5-Fluoro-2-hydroxypyridine is synthesised using 5-fluoro-2-methoxypyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
A total of 4.6 L of toluene solution containing 3-80 was placed in several sealed tubes and treated with 900 ml of 35percent HCl at 145° C. for 2 hr. LC/MS showed no starting material, only 4. The toluene solution was decanted and discarded. The aqueous phase was washed with EtOAc and concentrated down to remove volatiles to afford a brown solid containing the desired fluoro-hydroxypyridine 4-80. [1488] A total of 244 g of this solid was collected and taken to next step as is (it was not completely dry). [1489] Note: We have subsequently run this by decanting the toluene layer first prior to heating to reduce volumes. Same reaction was carried out using HBr (48percent in H2O) at 100° C. for 6 h with similar result to the literature procedure 49percent yield. [1490] Ref: J. Heterocyclic Chem., 10, 779, 1973 (for above Reactions, Including Analytical Data).
5-Fluoro-2-hydroxypyridine synthesis

Properties of 5-Fluoro-2-hydroxypyridine

Melting point: 150-155°C
Boiling point: 251.7±40.0 °C(Predicted)
Density  1.26±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
form  Crystalline Powder
pka 10.09±0.10(Predicted)
color  White to off-white
CAS DataBase Reference 51173-05-8(CAS DataBase Reference)

Safety information for 5-Fluoro-2-hydroxypyridine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for 5-Fluoro-2-hydroxypyridine

InChIKey KLULSYPVWLJZAO-UHFFFAOYSA-N

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