Chromium picolinate
Synonym(s):Cr(pic)3;CrPic
- CAS NO.:14639-25-9
- Empirical Formula: C18H12CrN3O6
- Molecular Weight: 418.3
- MDL number: MFCD00068715
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is Chromium picolinate?
Chemical properties
Dark violet crystal
The Uses of Chromium picolinate
Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.
Background
Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are shown to regulate insulin by promoting glucose utilization and increasing the sensitivity of the insulin receptor .
Health benefits
Chromium is involved in the metabolism of carbohydrates, proteins, and fats. In this role, chromium picolinate provides a number of physical health benefits. Some of the benefits of chromium are:
Enhances lean body mass
Promotes healthy blood glucose levels
Supports healthy blood pressure
Chromium also helps convert glucose into energy. In this capacity, it may provide positive effects on insulin resistance, which is a precursor to diabetes.
Side Effects
Allergic reaction
Cramps or pain in the muscles
Signs of low blood sugar (confusion, dizziness, sweating, shaky, clammy skin)
Urinary tract issues or changes
General Description
Chromium picolinate is a supplemental or alternative medication for type 2 diabetes and an anti-diabetic mechanisms of CrPic in insulin-resistant 3T3-L1 adipocytes.
Biochem/physiol Actions
Chromium picolinate (CrPic) is a supplemental or alternative medication for type 2 diabetes. Experimental evidence shows the effect of CrPic on glucose uptake through the activation of p38 MAPK. Chromium is thought to potentiate the action of insulin, leading to increased insulin sensitivity in type 2 diabetes.
Metabolism
Chromium picolinate was found to be stable in rat stomach and small intestine contents in vitro, consistent with a previous study [110]. It was inferred that the complex disassociated at or near the intestinal wall, and the absorbed picolinic acid was excreted mainly as N-picolylglycine; however, ~8–10% of the radiolabel was excreted from the breath as CO2, plus an unidentified major metabolite was observed in mice along with N-picolylglycine[1]. Adipose, blood, and liver showed Cr levels 2–6 times higher than untreated animals, with the liver containing the highest amounts.
References
[1] Stearns, D. “Evaluation of chromium(III) genotoxicity with cell culture and in vitro assays.” 2007.
Properties of Chromium picolinate
Melting point: | >300°C |
storage temp. | room temp |
solubility | DMSO (Slightly, Heated) |
form | Solid |
color | Dark Red |
Odor | at 100.00?%. odorless |
Merck | 14,2236 |
InChI | InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3 |
CAS DataBase Reference | 14639-25-9(CAS DataBase Reference) |
EPA Substance Registry System | Chromium, tris(2-pyridinecarboxylato-.kappa.N1,.kappa.O2)- (14639-25-9) |
Safety information for Chromium picolinate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for Chromium picolinate
InChIKey | CBDQOLKNTOMMTL-UHFFFAOYSA-K |
SMILES | O=C1C2C=CC=CN=2[Cr+3]23([O-]C(=O)C4C=CC=CN2=4)([O-]C(=O)C2C=CC=CN3=2)[O-]1 |
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