DMT-dT Phosphoramidite

Synonym(s):5′-O-(4,4′-dimethoxytrityl)-2′-deoxythymidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite];5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxythymidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];DMT-dT amidite;DMT-dT Phosphoramidite;Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS NO.：98796-51-1
Empirical Formula: C40H49N4O8P
Molecular Weight: 744.81
MDL number: MFCD00055063
EINECS: 685-410-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-15 10:57:57

What is DMT-dT Phosphoramidite?

The Uses of DMT-dT Phosphoramidite

5''-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3''-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a nucleotide and reactant used in the solid-phase synthesis of phosphorothioate oligonucleotides, and in the synthesis of lipophilic 5''-phosphoramidate derivatives of DNA and RNA oligonucleotides.

Chemical properties

5'-O-DMT-Thymidine-CE Phosphoramidite is also known as DMT-dT Phosphoramidite. The IUPAC Name of this compound is (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It allows for the introduction of thymidine units into oligonucleotides. Also, it has been used in various applications, including the synthesis of natural and unnatural DNA and RNA strands.

The Uses of DMT-dT Phosphoramidite

Properties of DMT-dT Phosphoramidite

Density	1.22 at 20℃
vapor pressure	0-0Pa at 20-50℃
storage temp.	Sealed in dry,2-8°C
solubility	soluble, clear
form	powder or granules
pka	9.55±0.10(Predicted)
color	white to off-white

Safety information for DMT-dT Phosphoramidite

Computed Descriptors for DMT-dT Phosphoramidite

InChIKey	UNOTXUFIWPRZJX-DJKSPSSYNA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,38,r\|