5-Chloro-1-indanone
- CAS NO.:42348-86-7
- Empirical Formula: C9H7ClO
- Molecular Weight: 166.6
- MDL number: MFCD00041456
- EINECS: 610-016-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is 5-Chloro-1-indanone?
Chemical properties
White Crystal
The Uses of 5-Chloro-1-indanone
5-Chloro-1-indanone is the important intermediate of du pont company's new varieties of pesticides indoxacarb (popular name: indoxacarb), is also a kind of important medicine intermediate simultaneously.
5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types.
5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors.
The Uses of 5-Chloro-1-indanone
5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may also be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors. It participates in the Irie?s synthesis of substituted pyridines.
Preparation
3-chlorobenzaldehyde as raw material first reacts with propionic acid to prepare 3-chloro-phenylpropionic acid, which is then subjected to Friedel-Crafts acylation reaction to prepare 5-chloro-1-indanone. Organic solvents of formic acid diethylamine participate in the first step, and the reaction temperature is 20-150℃. An organic solvent of methylene chloride and a catalyst of zinc chloride participate in the second step, and the reaction temperature is -10 to 80 ℃.
Synthetic method of 5-chloro-1-indanone
General Description
5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types.
Properties of 5-Chloro-1-indanone
Melting point: | 94-98 °C (lit.) |
Boiling point: | 124-125 °C (3 mmHg) |
Density | 1.1466 (rough estimate) |
refractive index | 1.6000 (estimate) |
Flash point: | 124-125°C/3mm |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly) |
form | Solid |
color | Light Beige to Beige |
Water Solubility | insoluble |
BRN | 1448000 |
CAS DataBase Reference | 42348-86-7(CAS DataBase Reference) |
NIST Chemistry Reference | 5-Chloro-1-indanone(42348-86-7) |
EPA Substance Registry System | 1H-Inden-1-one, 5-chloro-2,3-dihydro- (42348-86-7) |
Safety information for 5-Chloro-1-indanone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Chloro-1-indanone
InChIKey | MEDSHTHCZIOVPU-UHFFFAOYSA-N |
5-Chloro-1-indanone manufacturer
ARRKEM LIFE SCIENCES PRIVATE LIMITED
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