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HomeProduct name list5-Aminofluorescein

5-Aminofluorescein

  • CAS NO.:3326-34-9
  • Empirical Formula: C20H13NO5
  • Molecular Weight: 347.32
  • MDL number: MFCD00005052
  • EINECS: 222-043-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
5-Aminofluorescein Structural

What is 5-Aminofluorescein?

Chemical properties

Dark Red Solid

The Uses of 5-Aminofluorescein

Glycosaminoglycuronans react with 5-aminofluorescein to yield fluorescent derivatives. 5-aminofluorescein is also used to prepare FITC Isomer I (F-011, F-020).

The Uses of 5-Aminofluorescein

5-aminofluorescein is also used to prepare FITC Isomer I (CDX-F0011, CDX-F0020). It is a chemical used as molecular probe and important as fluorescent dye and for derivatives. Fluorescent labeling reagent for proteins. Used in the fluorescent antibody technique for rapid identification of pathogens.

What are the applications of Application

Fluoresceinamine, isomer I is a reagent for fluorescence studies

Definition

ChEBI: 5-aminofluorescein is a primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid. It derives from a fluorescein (lactone form).

Preparation

The preparation of 5-aminofluorescein is carried out either by first saponification of 5-nitrofluorescein acetates with alcohol alkali, followed by reduction of the obtained 5-nitrofluorescein in a solution of alcohol alkali with hydrazine hydrate on a nickel catalyst to obtain 5-aminofluorescein , Or by boiling in an aqueous solution of sodium sulfide. The restoration of the nitro group and the saponification of acetates in the second case occurs in one stage.

General Description

Fluoresceinamine, isomer I belongs to the class of derivatized fluoresceins.

Properties of 5-Aminofluorescein

Melting point: 223 °C (dec.)(lit.)
Boiling point: 481.89°C (rough estimate)
Density  1.3724 (rough estimate)
refractive index  1.5180 (estimate)
storage temp.  room temp
solubility  DMF: 5 mg/ml; DMSO: 5 mg/ml
pka 9.34±0.20(Predicted)
form  powder
color  red-brown
Water Solubility  Soluble in water (partly), methanol (10 mg/ml), and acetone.
BRN  48395
Stability: Light and Moisture Sensitive
CAS DataBase Reference 3326-34-9(CAS DataBase Reference)
EPA Substance Registry System Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy- (3326-34-9)

Safety information for 5-Aminofluorescein

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Aminofluorescein

InChIKey GZAJOEGTZDUSKS-UHFFFAOYSA-N

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