5-Aminofluorescein
- CAS NO.:3326-34-9
- Empirical Formula: C20H13NO5
- Molecular Weight: 347.32
- MDL number: MFCD00005052
- EINECS: 222-043-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is 5-Aminofluorescein?
Chemical properties
Dark Red Solid
The Uses of 5-Aminofluorescein
Glycosaminoglycuronans react with 5-aminofluorescein to yield fluorescent derivatives. 5-aminofluorescein is also used to prepare FITC Isomer I (F-011, F-020).
The Uses of 5-Aminofluorescein
5-aminofluorescein is also used to prepare FITC Isomer I (CDX-F0011, CDX-F0020). It is a chemical used as molecular probe and important as fluorescent dye and for derivatives. Fluorescent labeling reagent for proteins. Used in the fluorescent antibody technique for rapid identification of pathogens.
What are the applications of Application
Fluoresceinamine, isomer I is a reagent for fluorescence studies
Definition
ChEBI: 5-aminofluorescein is a primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid. It derives from a fluorescein (lactone form).
Preparation
The preparation of 5-aminofluorescein is carried out either by first saponification of 5-nitrofluorescein acetates with alcohol alkali, followed by reduction of the obtained 5-nitrofluorescein in a solution of alcohol alkali with hydrazine hydrate on a nickel catalyst to obtain 5-aminofluorescein , Or by boiling in an aqueous solution of sodium sulfide. The restoration of the nitro group and the saponification of acetates in the second case occurs in one stage.
General Description
Fluoresceinamine, isomer I belongs to the class of derivatized fluoresceins.
Properties of 5-Aminofluorescein
Melting point: | 223 °C (dec.)(lit.) |
Boiling point: | 481.89°C (rough estimate) |
Density | 1.3724 (rough estimate) |
refractive index | 1.5180 (estimate) |
storage temp. | room temp |
solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml |
pka | 9.34±0.20(Predicted) |
form | powder |
color | red-brown |
Water Solubility | Soluble in water (partly), methanol (10 mg/ml), and acetone. |
BRN | 48395 |
Stability: | Light and Moisture Sensitive |
CAS DataBase Reference | 3326-34-9(CAS DataBase Reference) |
EPA Substance Registry System | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy- (3326-34-9) |
Safety information for 5-Aminofluorescein
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Aminofluorescein
InChIKey | GZAJOEGTZDUSKS-UHFFFAOYSA-N |
Abamectin manufacturer
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