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HomeProduct name list5-Amino-2,4,6-triiodoisophthaloyl dichloride

5-Amino-2,4,6-triiodoisophthaloyl dichloride

  • CAS NO.:37441-29-5
  • Empirical Formula: C8H2Cl2I3NO2
  • Molecular Weight: 595.73
  • MDL number: MFCD00270836
  • EINECS: 417-220-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-28 19:59:05
5-Amino-2,4,6-triiodoisophthaloyl dichloride Structural

What is 5-Amino-2,4,6-triiodoisophthaloyl dichloride?

Description

5-Amino-2,4,6-triiodisophthaloyl acid dichloride is a triiodinated compound that has been shown to bind to the receptor for asialoglycoprotein. It is used in the diagnosis of liver and kidney diseases. 5-Amino-2,4,6-triiodisophthaloyl acid dichloride is taken up by tissues and organs and causes damage to these tissues. The chloride ion binds to the molecule, making it more water soluble. The lactobionic acid residue is then cleaved off by an enzyme in the cell called beta-galactosidase. This leaves a molecule containing iodine which can be detected with a diagnostic technique such as X-ray crystallography or nuclear magnetic resonance spectroscopy.

Chemical properties

Yellow Solid

The Uses of 5-Amino-2,4,6-triiodoisophthaloyl dichloride

5-Amino-2,4,6- triiodisophthaloyl acid dichloride is used in the preparation of trimeric X-ray contrast agents.

Preparation

5-Amino-2,4,6-triiodo-isophtalic acid (30 g, 0.054 mol), thionyl chloride (8.2 ml, 0.113 mol) and pyridine (0.2 ml) in 1 ,2 dichloroethane (20 ml) were heated to 70 ℃. A portion of thionyl chloride (15.2 ml, 0.21 mol) was added dropwise during 2 h, and the mixture was heated to 85 ℃ for 6 h. After cooling the reaction mixture to room temperature, it was poured into 300 g of ice-water. The yellow precipitate was filtered off, sucked dry and then washed with water until pH=5. The filter cake was then dried in a vacuum oven for 3 hrs. A light yellow powder was obtained as 5-Amino-2,4,6-triiodisophthaloyl acid dichloride.
5-Amino-2,4,6-triiodisophthaloyl acid dichloride

Flammability and Explosibility

Not classified

Properties of 5-Amino-2,4,6-triiodoisophthaloyl dichloride

Melting point: 231°C(lit.)
Boiling point: 566.9±50.0 °C(Predicted)
Density  2.826±0.06 g/cm3(Predicted)
vapor pressure  0.018Pa at 20℃
storage temp.  Refrigerator, under inert atmosphere
solubility  Acetone (Slightly), Methanol (Very Slightly)
form  Solid
pka -3.45±0.10(Predicted)
color  Yellow toDark Brown
λmax 233nm(MeOH)(lit.)
CAS DataBase Reference 37441-29-5(CAS DataBase Reference)

Safety information for 5-Amino-2,4,6-triiodoisophthaloyl dichloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P272:Contaminated work clothing should not be allowed out of the workplace.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P391:Collect spillage. Hazardous to the aquatic environment
P501:Dispose of contents/container to..…

Computed Descriptors for 5-Amino-2,4,6-triiodoisophthaloyl dichloride

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