4,7-Dichloroquinoline
Synonym(s):4,7-Dichloroquinoline
- CAS NO.：86-98-6
- Empirical Formula: C9H5Cl2N
- Molecular Weight: 198.05
- MDL number: MFCD00006774
- EINECS: 201-714-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is 4,7-Dichloroquinoline?
Chemical properties
white to light yellow crystal powder
The Uses of 4,7-Dichloroquinoline
4,7-Dichloroquinoline is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti -microbial agents showing efficacy against common bacterial strains. Chloroquinoline impurity.
The Uses of 4,7-Dichloroquinoline
4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It was used in the synthesis of piperaquine. and as starting reagent in the synthesis of {3-amino-5-[(7-chloro-4-quinolyl)amino]phenyl}methanol.
General Description
Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.
Flammability and Explosibility
Not classified
Synthesis
4,7-Dichloroquinoline is obtained by chlorination of 7-chloro-4-hydroxyquinoline.
Purification Methods
Crystallise the dichloroquinoline from MeOH or 95% EtOH. [Beilstein 20/7 V 316.]
Hazard
4,7-Dichloroquinoline is a strong skin and eye irritant. Subcutaneous LDLo (mouse) = 80 mg/kg.
Properties of 4,7-Dichloroquinoline
| Melting point: | 81-83 °C (lit.) |
| Boiling point: | 298.4 °F (148°C) |
| Density | 1.4178 (rough estimate) |
| vapor pressure | 0.103Pa at 25℃ |
| refractive index | 1.6300 (estimate) |
| Flash point: | 164 °C |
| storage temp. | 2-30°C |
| solubility | chloroform: soluble50mg/mL, clear, colorless to greenish-yellow |
| form | Powder |
| pka | 1.99±0.27(Predicted) |
| color | White to pale brown |
| Water Solubility | insoluble |
| BRN | 125359 |
| CAS DataBase Reference | 86-98-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Quinoline, 4,7-dichloro-(86-98-6) |
| EPA Substance Registry System | 4,7-Dichloroquinoline (86-98-6) |
Safety information for 4,7-Dichloroquinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4,7-Dichloroquinoline
| InChIKey | HXEWMTXDBOQQKO-UHFFFAOYSA-N |
4,7-Dichloroquinoline manufacturer
TAGOOR LABORATORIES PVT LTD
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Phone:+91-9505502670
Whatsapp: +91- 9505502670
product: 86-98-6 4,7-dichloroquinoline (4,7-DCQ) >98%
Navitus Chemicals Pvt Ltd
1Y
Phone:+undefined9370559385
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SRIKAR Labs
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Phone:+919177846399
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product: 4,7-Dichloroquinoline 86-98-6 98%
Glyra Health Care Pvt Ltd
Phone:+91-9727720767
Whatsapp: +91-9727720767
product: 86-98-6 4,7-Dichloroquinoline 99%
Exemed Pharmaceuticals (Oneiro Chemicals Pvt Ltd)
1Y
Phone:+919099061028
Whatsapp: +91-9099061028
product: 86-98-6 98%
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