4,7-Dichloroquinoline

Synonym(s):4,7-Dichloroquinoline

CAS NO.：86-98-6
Empirical Formula: C9H5Cl2N
Molecular Weight: 198.05
MDL number: MFCD00006774
EINECS: 201-714-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 15:18:15

What is 4,7-Dichloroquinoline?

Chemical properties

white to light yellow crystal powder

The Uses of 4,7-Dichloroquinoline

4,7-Dichloroquinoline is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti -microbial agents showing efficacy against common bacterial strains. Chloroquinoline impurity.

The Uses of 4,7-Dichloroquinoline

4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It was used in the synthesis of piperaquine. and as starting reagent in the synthesis of {3-amino-5-[(7-chloro-4-quinolyl)amino]phenyl}methanol.

General Description

Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Flammability and Explosibility

Not classified

Synthesis

4,7-Dichloroquinoline is obtained by chlorination of 7-chloro-4-hydroxyquinoline.

Purification Methods

Crystallise the dichloroquinoline from MeOH or 95% EtOH. [Beilstein 20/7 V 316.]

Hazard

4,7-Dichloroquinoline is a strong skin and eye irritant. Subcutaneous LDLo (mouse) = 80 mg/kg.

Properties of 4,7-Dichloroquinoline

Melting point:	81-83 °C (lit.)
Boiling point:	298.4 °F (148°C)
Density	1.4178 (rough estimate)
vapor pressure	0.103Pa at 25℃
refractive index	1.6300 (estimate)
Flash point:	164 °C
storage temp.	2-30°C
solubility	chloroform: soluble50mg/mL, clear, colorless to greenish-yellow
form	Powder
pka	1.99±0.27(Predicted)
color	White to pale brown
Water Solubility	insoluble
BRN	125359
CAS DataBase Reference	86-98-6(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 4,7-dichloro-(86-98-6)
EPA Substance Registry System	4,7-Dichloroquinoline (86-98-6)

Safety information for 4,7-Dichloroquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.