4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Synonym(s):Caramel furanone;Sotolon;Sugar lactone
- CAS NO.:28664-35-9
- Empirical Formula: C6H8O3
- Molecular Weight: 128.13
- MDL number: MFCD00059957
- EINECS: 249-136-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-25 20:04:51
What is 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one?
Chemical properties
clear yellow liquid
Chemical properties
3-Hydroxy-4,5-dimethyl-2(5H)-furanone was found in, for example, fenugreek, coffee, sake, and florsherry. Its aroma characteristic changes from caramel-like at low concentrations to curry-like at high concentrations. A method described for its preparation comprises condensation of ethyl propionate with diethyl oxalate and reaction of the intermediately formed diethyl oxalylpropionate with acetaldehyde. Acidic decarboxylation of the ethyl 4,5-dimethyl-2,3-dioxodihydrofuran-4-carboxylate gives the title compound.
Occurrence
Reported found in roasted Virginia tobacco, beef broth, beer, sherry, botryized wine, coffee, tea, fenugreek, sake and rice wine.
The Uses of 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C3 is a labelled analogue of 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (D473600). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is a fragrant compound that is a key indicator of maple syrup urine disease, a disorder affecting newborn children that is the result of its inability to properly metabolize Valine (V094205), Leucine (L330110) and Isoleucine (I820175). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is naturally found in fenugreek seeds, and is an odourant present in sherry wines.
Definition
ChEBI: Sotolone is a butenolide. It has a role as a metabolite.
Aroma threshold values
Aroma characteristics at 1.0%; sweet, strong brown, cyclotene and maple like, caramel, toffee, maltol-like and burnt, brown sugar fenugreek-like, cooked and syrupy.
Taste threshold values
Taste characteristics at 5–25 ppm; sweet, caramel, maple, walnut, brown sugar, nutty, cotton candy, fenugreek and celery-like, rum, roasted meaty with a honey nuance
Properties of 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Melting point: | 26-29 °C(lit.) |
Boiling point: | 184 °C(lit.) |
Density | 1.049 g/mL at 25 °C |
refractive index | n |
FEMA | 3634 | 4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE |
Flash point: | >230 °F |
storage temp. | Sealed in dry,2-8°C |
form | neat |
pka | 9.28±0.40(Predicted) |
Odor | at 0.01 % in propylene glycol. extremely sweet strong caramel maple burnt sugar coffee |
JECFA Number | 243 |
CAS DataBase Reference | 28664-35-9(CAS DataBase Reference) |
NIST Chemistry Reference | 2(5H)-furanone, 3-hydroxy-4,5-dimethyl-(28664-35-9) |
EPA Substance Registry System | 2(5H)-Furanone, 3-hydroxy-4,5-dimethyl- (28664-35-9) |
Safety information for 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
InChIKey | UNYNVICDCJHOPO-UHFFFAOYSA-N |
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