4-(Trimethylsilyl)-3-butyn-2-one
- CAS NO.：5930-98-3
- Empirical Formula: C7H12OSi
- Molecular Weight: 140.26
- MDL number: MFCD00190212
- EINECS: 628-294-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-(Trimethylsilyl)-3-butyn-2-one?
Chemical properties
clear slightly yellow liquid
The Uses of 4-(Trimethylsilyl)-3-butyn-2-one
4-(Trimethylsilyl)-3-butyn-2-one (TMSB) has been used to investigate its asymmetric bioreduction to (S)-4-(trimethylsilyl)-3-butyn-2-ol {(S)-TMSBOL} by employing biocompatible water-immiscible ionic liquids (ILs). TMSB may be used for the synthesis of entecavir (BMS-200475).
General Description
4-(Trimethylsilyl)-3-butyn-2-one is a ketone. Its asymmetric bioreduction to enantiopure {(S)-TMSBOL in various hydrophilic ionic liquid (ILs) solvent systems has been reported.
Properties of 4-(Trimethylsilyl)-3-butyn-2-one
| Melting point: | 99 °C |
| Boiling point: | 156 °C(lit.) |
| Density | 0.854 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 83 °F |
| storage temp. | Flammables area |
| form | clear liquid |
| Specific Gravity | 0.854 |
| color | Colorless to Light yellow to Light orange |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| CAS DataBase Reference | 5930-98-3(CAS DataBase Reference) |
Safety information for 4-(Trimethylsilyl)-3-butyn-2-one
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(Trimethylsilyl)-3-butyn-2-one
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