4-Aminobenzotrifluoride

Synonym(s):α,α,α-Trifluoro-p-toluidine;4-(Trifluoromethyl)aniline;4-Aminobenzotrifluoride

CAS NO.：455-14-1
Empirical Formula: C7H6F3N
Molecular Weight: 161.12
MDL number: MFCD00064396
EINECS: 207-236-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 18:15:48

What is 4-Aminobenzotrifluoride?

Chemical properties

clear colorless to yellow liquid

The Uses of 4-Aminobenzotrifluoride

4-Substituted aniline derivatives exert special hematotoxicity on the red blood cells and induce leukocytosis.

The Uses of 4-Aminobenzotrifluoride

4-(Trifluoromethyl)aniline was used in the synthesis of 4-(trialkylmethyl)anilines. It was also used as a synthetic building block.

Definition

ChEBI: A substituted aniline that is a benzene ring substituted with an amino group at position 1 and a trifluoromethyl group at position 4.

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Properties of 4-Aminobenzotrifluoride

Melting point:	3-8 °C
Boiling point:	83 °C12 mm Hg(lit.)
Density	1.283 g/mL at 25 °C(lit.)
refractive index	n20/D 1.483(lit.)
Flash point:	188 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Liquid
pka	2.45(at 25℃)
Specific Gravity	1.283
color	Clear colorless to yellow
Water Solubility	<0.1 g/100 mL
Sensitive	Air Sensitive
BRN	1564853
CAS DataBase Reference	455-14-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 4-(trifluoromethyl)-(455-14-1)
EPA Substance Registry System	4-(Trifluoromethyl)aniline (455-14-1)

Safety information for 4-Aminobenzotrifluoride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H318:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.