4-(Trifluoromethyl)phenylacetic acid
Synonym(s):(α,α,α-Trifluoro-p-tolyl)acetic acid
- CAS NO.：32857-62-8
- Empirical Formula: C9H7F3O2
- Molecular Weight: 204.15
- MDL number: MFCD00004352
- EINECS: 251-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-01 17:24:36
What is 4-(Trifluoromethyl)phenylacetic acid?
Chemical properties
white to very pale yellow crystals or
The Uses of 4-(Trifluoromethyl)phenylacetic acid
4-(Trifluoromethyl)benzeneacetic Acid is an intermediate used to synthesize PPARγ/δ dual agonists via solid-Phase parallel synthesis. It was also used to prepare heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
General Description
4-(Trifluoromethyl)phenylacetic acid undergoes diolefination mediated by mono-N-protected amino acid ligands in the presence of ethyl acrylate, Pd(OAc)2, KHCO3 and t-amyl alcohol.
Properties of 4-(Trifluoromethyl)phenylacetic acid
| Melting point: | 82-85 °C(lit.) |
| Boiling point: | 203°C (rough estimate) |
| Density | 1.2815 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystals or Crystalline Powder |
| pka | 4.01±0.10(Predicted) |
| color | White to very pale yellow |
| BRN | 2267687 |
| CAS DataBase Reference | 32857-62-8(CAS DataBase Reference) |
| NIST Chemistry Reference | («ALPHA»,«alpha»,«alpha»-trifluoro-p-tolyl)-acetic acid(32857-62-8) |
Safety information for 4-(Trifluoromethyl)phenylacetic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(Trifluoromethyl)phenylacetic acid
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