1-Bromo-4-(trifluoromethoxy)benzene

Synonym(s):1-Bromo-4-(trifluoromethoxy)benzene;p-Trifluoromethoxy bromo benzene

CAS NO.：407-14-7
Empirical Formula: C7H4BrF3O
Molecular Weight: 241.01
MDL number: MFCD00040834
EINECS: 206-979-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

1-Bromo-4-(trifluoromethoxy)benzene Structural

What is 1-Bromo-4-(trifluoromethoxy)benzene?

Chemical properties

CLEAR COLOURLESS TO YELLOW LIQUID

The Uses of 1-Bromo-4-(trifluoromethoxy)benzene

1-Bromo-4-(trifluoromethoxy)benzene was used in the synthesis of 4-{[4-[(2-ethylhexyloxy)-6-(4-morpholinylmethyl)-4-trifluoromethyl][1,1-biphenyl]-3-yl]methyl}morpholine.

Synthesis Reference(s)

Journal of the American Chemical Society, 109, p. 3708, 1987 DOI: 10.1021/ja00246a030

General Description

1-Bromo-4-(trifluoromethoxy)benzene on treatment with lithium diisopropylamide (LIDA) at -100°C gives 5-bromo-2-(trifluoromethoxy)phenyllithium and at -75°C it eliminates lithium bromide, thus generating 1,2-dehydro-4-(trifluoromethoxy)benzene.

Properties of 1-Bromo-4-(trifluoromethoxy)benzene

Boiling point:	80 °C50 mm Hg(lit.)
Density	1.622 g/mL at 25 °C(lit.)
vapor pressure	20 hPa (55 °C)
refractive index	n20/D 1.461(lit.)
Flash point:	154 °F
storage temp.	Sealed in dry,Room Temperature
solubility	11.7mg/l
form	Liquid
color	Clear colorless to yellow
Specific Gravity	1.64
BRN	2046332
InChI	InChI=1S/C7H4BrF3O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
CAS DataBase Reference	407-14-7(CAS DataBase Reference)
NIST Chemistry Reference	P-bromophenyl trifluoromethyl ether(407-14-7)

Safety information for 1-Bromo-4-(trifluoromethoxy)benzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.