4-(N,N-Dimethylamino)butanal Dimethyl Acetal
- CAS NO.:19718-92-4
- Empirical Formula: C8H19NO2
- Molecular Weight: 161.24
- MDL number: MFCD06411126
- EINECS: 606-363-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-28 19:59:05
What is 4-(N,N-Dimethylamino)butanal Dimethyl Acetal?
Chemical properties
Pale Brown Oil.
The Uses of 4-(N,N-Dimethylamino)butanal Dimethyl Acetal
4-(N,N-Dimethylamino)butanal Dimethyl Acetal is a reactant used in the synthesis of hallucinogenic tryptamines.
General Description
4-(N,N-Dimethylamino)butanal Dimethyl Acetal is the acetal of 4-(N,N-dimethylamino)butanal. It is soluble in organic solvents and can be used as a building block for various organic syntheses, such as the synthesis of amides or sulfones. 4-(N,N-Dimethylamino)butanal Dimethyl Acetal has a high yield and can be prepared in one step by reacting methanesulfonic acid with dimethyl acetaldehyde. This reaction requires sulfuric acid and methane as catalysts.
Synthesis
synthesis of 4-(N,N-Dimethylamino)butanal dimethyl acetal: 4- Chlorobutanal dimethyl acetal (2) (100 g, 0.655 mol) was dissolved in aqueous dimethyl amine solution (200 mL) and the solution is stirred for 15 min at ambient temperature. The reaction mixture was then warmed to 50 oC and stirred for 3 h. After the reaction mixture was cooled to room temperature, the product was extracted with methylene chloride (2 × 250 mL). The combined organic layers were washed with 5 % NaHCO3 solution (2 × 100 mL) and brine solution (2 × 100 mL). The organic layer was evaporated and the residue was distilled to afford 88 g (84 %) of 4-(N,Ndimethylamino)butanal dimethyl acetal as a colourless liquid with 99.6 % purity by GC: b.p. 40 oC/1 mm Hg.
(a) (i) Sodium carbonate, dichloromethane, 5 oC, 0.5 h (ii) Methanol, conc. H2SO4, room temperature, 3 h, 87 %. (b) Aqueous dimethyl amine solution (30 %), 50 oC, 3 h, 76.0 %
1H NMR (CDCl3, 200 MHz): δ 1.47-1.63 (m, 4H), 2.21 (s, 6H), 2.24 (t, J = 7.0 Hz, 2H), 3.31 (s, 6H), 4.37 (t, J = 5.4 Hz, 2H). IR (cm-1): 2945 (-CH2-), 2816 (-CH-), 1464 (C-N), 1074 (-C-O-). Mass: m/z 162.5 (M+1).
Properties of 4-(N,N-Dimethylamino)butanal Dimethyl Acetal
Boiling point: | 164°C |
Density | 0.892 |
refractive index | 1.4200-1.4240 |
Flash point: | 25°C |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
pka | 9.71±0.28(Predicted) |
form | clear liquid |
color | Colorless to Light yellow |
Stability: | Moisture Sensitive |
InChI | InChI=1S/C8H19NO2/c1-9(2)7-5-6-8(10-3)11-4/h8H,5-7H2,1-4H3 |
CAS DataBase Reference | 19718-92-4(CAS DataBase Reference) |
Safety information for 4-(N,N-Dimethylamino)butanal Dimethyl Acetal
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-(N,N-Dimethylamino)butanal Dimethyl Acetal
InChIKey | WDZKKBDOGYBYBG-UHFFFAOYSA-N |
SMILES | C(N(C)C)CCC(OC)OC |
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