Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list4-Nitrophthalic anhydride

4-Nitrophthalic anhydride

  • CAS NO.:5466-84-2
  • Empirical Formula: C8H3NO5
  • Molecular Weight: 193.11
  • MDL number: MFCD00005922
  • EINECS: 226-776-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-24 19:19:26
4-Nitrophthalic anhydride Structural

What is 4-Nitrophthalic anhydride?

Chemical properties

off-white to light yellow-brown powder. Soluble in hot alcohol, hot acetic acid and acetone, insoluble in water.

The Uses of 4-Nitrophthalic anhydride

4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).

The Uses of 4-Nitrophthalic anhydride

5-Nitrophthalic Anhydride is used in the preparation of phthalic acids as well as compounds with anticonvulsant activities.

Preparation

4-Nitrophthalic anhydride is synthesized by hydrolysis of 4-nitrophthalimide and then dehydration. The 4-nitrophthalimide was added to the sodium hydroxide solution, heated and boiled for 15min. Adjust pH to 6-8 with nitric acid, and add nitric acid to boil for 5 min. Cooling, filtering, the filtrate was extracted with ether, the extract was dried and then the ether was evaporated, that is, 4-Nitrophthalic anhydride crystals were precipitated. Yield 95%.

General Description

Yellow powder.

Air & Water Reactions

Reacts with water. The organic acids produced by this reaction are significantly more soluble in water.

Reactivity Profile

4-Nitrophthalic anhydride reacts exothermically with water. The reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Fire Hazard

Flash point data for 4-Nitrophthalic anhydride are not available, however 4-Nitrophthalic anhydride is probably combustible.

Purification Methods

Distil the anhydride in a vacuum and/or recrystallise it from *C6H6 or Et2O/pet ether. Dry it in vacuo. It forms addition compounds with anthracene (m 118o), and phenanthrene (m 96o). [Beilstein 17 III/IV 6150, 17/11 V 267.]

Precautions

Moisture Sensitive. Store away from strong bases and oxidizing agents. Incompatible with water, bases, strong acids and oxidizing agents.

Properties of 4-Nitrophthalic anhydride

Melting point: 116-120 °C(lit.)
Boiling point: 197 °C / 8mmHg
Density  1.6392 (rough estimate)
refractive index  1.4700 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form  Solid
color  Pale Beige
Water Solubility  Hydrolysis
Sensitive  Moisture Sensitive
BRN  179682
CAS DataBase Reference 5466-84-2(CAS DataBase Reference)
NIST Chemistry Reference 4-Nitrophthalic anhydride(5466-84-2)
EPA Substance Registry System 5-Nitrophthalic anhydride (5466-84-2)

Safety information for 4-Nitrophthalic anhydride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Nitrophthalic anhydride

Related products of tetrahydrofuran

You may like

  • 5466-84-2 4-nitro pthalic anhydride 98%
    5466-84-2 4-nitro pthalic anhydride 98%
    5466-84-2
    View Details
  • 4-Nitrophthalic Anhydride CAS 5466-84-2
    4-Nitrophthalic Anhydride CAS 5466-84-2
    5466-84-2
    View Details
  • 4-Nitrophthalic anhydride CAS 5466-84-2
    4-Nitrophthalic anhydride CAS 5466-84-2
    5466-84-2
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.