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HomeProduct name list4-Nitrobenzyl hydrogen malonate

4-Nitrobenzyl hydrogen malonate

4-Nitrobenzyl hydrogen malonate Structural

What is 4-Nitrobenzyl hydrogen malonate?

The Uses of 4-Nitrobenzyl hydrogen malonate

4-Nitrobenzyl hydrogen malonate is a reagent used in the synthesis of (±)-thienamycin, a β-Lactam antibiotics. Also, it is useful for chiral key intermediate of carbapenem syntheses.

Preparation

Preparation of mono-4-nitrobenzyl malonate:
In a flame-dried 150 mL pressure tube under argon, add 5.00 g (34.7 mmol) of Meldrum's acid and 40 mL of anhydrous MeCN.
Add 5.58 g (36.4 mmol) of p-nitrobenzyl alcohol to the resulting solution.
Cap the tube tightly and reflux the reaction overnight.
Concentrate the reaction mixture under reduced pressure.
Purify the residue using column chromatography with a 55/45 hexane/EtOAc mixture.
The resulting product is mono-4-nitrobenzyl malonate with a yield of 87%.

Properties of 4-Nitrobenzyl hydrogen malonate

Melting point: 109 °C
Boiling point: 455.8±30.0 °C(Predicted)
Density  1.447±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  soluble in Methanol
form  powder to crystal
pka 2.49±0.32(Predicted)
color  White to Almost white
CAS DataBase Reference 77359-11-6(CAS DataBase Reference)

Safety information for 4-Nitrobenzyl hydrogen malonate

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for 4-Nitrobenzyl hydrogen malonate

InChIKey RIGFMUNSTCPGNP-UHFFFAOYSA-N

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