4-Nitrobenzyl hydrogen malonate
- CAS NO.:77359-11-6
- Empirical Formula: C10H9NO6
- Molecular Weight: 239.18
- MDL number: MFCD00191556
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-24 21:11:45
What is 4-Nitrobenzyl hydrogen malonate?
The Uses of 4-Nitrobenzyl hydrogen malonate
4-Nitrobenzyl hydrogen malonate is a reagent used in the synthesis of (±)-thienamycin, a β-Lactam antibiotics. Also, it is useful for chiral key intermediate of carbapenem syntheses.
Preparation
Preparation of mono-4-nitrobenzyl malonate:
In a flame-dried 150 mL pressure tube under argon, add 5.00 g (34.7 mmol) of Meldrum's acid and 40 mL of anhydrous MeCN.
Add 5.58 g (36.4 mmol) of p-nitrobenzyl alcohol to the resulting solution.
Cap the tube tightly and reflux the reaction overnight.
Concentrate the reaction mixture under reduced pressure.
Purify the residue using column chromatography with a 55/45 hexane/EtOAc mixture.
The resulting product is mono-4-nitrobenzyl malonate with a yield of 87%.
Properties of 4-Nitrobenzyl hydrogen malonate
Melting point: | 109 °C |
Boiling point: | 455.8±30.0 °C(Predicted) |
Density | 1.447±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
form | powder to crystal |
pka | 2.49±0.32(Predicted) |
color | White to Almost white |
CAS DataBase Reference | 77359-11-6(CAS DataBase Reference) |
Safety information for 4-Nitrobenzyl hydrogen malonate
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H341:Germ cell mutagenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-Nitrobenzyl hydrogen malonate
InChIKey | RIGFMUNSTCPGNP-UHFFFAOYSA-N |
Abamectin manufacturer
Ralington Pharma
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product: 77359-11-6 Mono p-nitro benzyl malonate 98%
Related products of tetrahydrofuran
Ethyl hydrogen malonate
4-(Benzyloxycarbonyl)-2-azetidinone
2-([(BENZYLOXY)CARBONYL]AMINO)-2-HYDROXYACETIC ACID
Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
Malonyl chloride
Methyl malonyl chloride
BPMO
Diethyl methylmalonate
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