4-Nitrobenzyl hydrogen malonate
- CAS NO.:77359-11-6
- Empirical Formula: C10H9NO6
- Molecular Weight: 239.18
- MDL number: MFCD00191556
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-24 21:11:45
What is 4-Nitrobenzyl hydrogen malonate?
The Uses of 4-Nitrobenzyl hydrogen malonate
4-Nitrobenzyl hydrogen malonate is a reagent used in the synthesis of (±)-thienamycin, a β-Lactam antibiotics. Also, it is useful for chiral key intermediate of carbapenem syntheses.
Preparation
Preparation of mono-4-nitrobenzyl malonate:
In a flame-dried 150 mL pressure tube under argon, add 5.00 g (34.7 mmol) of Meldrum's acid and 40 mL of anhydrous MeCN.
Add 5.58 g (36.4 mmol) of p-nitrobenzyl alcohol to the resulting solution.
Cap the tube tightly and reflux the reaction overnight.
Concentrate the reaction mixture under reduced pressure.
Purify the residue using column chromatography with a 55/45 hexane/EtOAc mixture.
The resulting product is mono-4-nitrobenzyl malonate with a yield of 87%.
Properties of 4-Nitrobenzyl hydrogen malonate
Melting point: | 109 °C |
Boiling point: | 455.8±30.0 °C(Predicted) |
Density | 1.447±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
form | powder to crystal |
pka | 2.49±0.32(Predicted) |
color | White to Almost white |
CAS DataBase Reference | 77359-11-6(CAS DataBase Reference) |
Safety information for 4-Nitrobenzyl hydrogen malonate
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H341:Germ cell mutagenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-Nitrobenzyl hydrogen malonate
InChIKey | RIGFMUNSTCPGNP-UHFFFAOYSA-N |
Abamectin manufacturer
Ralington Pharma
1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 77359-11-6 Mono p-nitro benzyl malonate 98%
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
Ethyl hydrogen malonate
4-(Benzyloxycarbonyl)-2-azetidinone
2-([(BENZYLOXY)CARBONYL]AMINO)-2-HYDROXYACETIC ACID
Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
Malonyl chloride
Methyl malonyl chloride
BPMO
Diethyl methylmalonate
You may like
-
77359-11-6 Mono p-nitro benzyl malonate 98%View Details
77359-11-6 -
Mono-4-nitrobenzyl Malonate CAS 77359-11-6View Details
77359-11-6 -
Mono-4-Nitrobenzyl malonate 98% (HPLC) CAS 77359-11-6View Details
77359-11-6 -
Dechloro DesloratadineView Details
-
Dehydro DesloratadineView Details
-
Edoxaban Impurity 57View Details
2089454-69-1 -
Empagliflozin Bromo ImpurityView Details
-
Ipratropium EP Impurity BView Details
58073-59-9
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.