Diethyl methylmalonate
Synonym(s):Methylmalonic acid diethyl ester
- CAS NO.:609-08-5
- Empirical Formula: C8H14O4
- Molecular Weight: 174.19
- MDL number: MFCD00009162
- EINECS: 210-175-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-13 16:08:25
What is Diethyl methylmalonate?
Chemical properties
Colorless mobile liquid. Slightly soluble in water, soluble in alcohol and oils.
The Uses of Diethyl methylmalonate
Diethyl methylmalonate is used as intermediate for the syntheses of pharmaceuticals, e.g. non-steroidal anti-inflammatory agents with 2-acrylpropionic acid structures acrylpropionic acid structure. It is also used in the flavour and fragrance industries. Product Data Sheet
The Uses of Diethyl methylmalonate
Diethyl methylmalonate was used to investigate the effect of direct supplementation of the medium with di-ester of methylmalonate on erythromycin fermentation in Saccharopolyspora erythraea mutB strain.
What are the applications of Application
Diethyl methylmalonate is A chemical that reacts with 2-cyclohexenone under abnormal Michael conditions form 2-(3-oxocyclohexyl)-2-cyclohexenone
General Description
Diethyl methylmalonate reacts with 2-cyclohexenone under abnormal Michael conditions form 2-(3-oxocyclohexyl)-2-cyclohexenone. It causes the alkylation of poly(chloromethylstyrene) during pahse transfer catalysis.
Synthesis
Diethyl methylmalonate is produced by the following method:1) by condensing Ethylpropionate with Diethyloxalate, followed by heating of the reaction product. 2) from Diethylmalonate plus Sodium and Methyl iodide.
Properties of Diethyl methylmalonate
Boiling point: | 198-199 °C (lit.)
78-80 °C/10 mmHg |
Density | 1.022 g/mL at 20 °C (lit.) |
refractive index | n |
Flash point: | 170 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | 1000mg/l |
form | Liquid |
pka | 13.13±0.46(Predicted) |
Specific Gravity | 1.013 |
color | Clear colorless |
PH | 8 (1000mg/l, H2O, 20℃) |
Water Solubility | immiscible |
BRN | 637028 |
CAS DataBase Reference | 609-08-5(CAS DataBase Reference) |
NIST Chemistry Reference | Propanedioic acid, methyl-, diethyl ester(609-08-5) |
EPA Substance Registry System | Propanedioic acid, methyl-, diethyl ester (609-08-5) |
Safety information for Diethyl methylmalonate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for Diethyl methylmalonate
InChIKey | UPQZOUHVTJNGFK-UHFFFAOYSA-N |
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