Malonyl chloride

Synonym(s):Malonyl dichloride

clear yellow to orange to brown liquid

Malonyl chloride can be used as a reactant for the synthesis of:

Alkaloids with tetracyclic cores such as cyclopiamide A and speradine E.
6-tetrathiafulvalene(TTF)-polymer by condensation polymerization with TTF-based dihydroxy monomer.
N-doped TiO₂ films by molecular layer deposition.
Alkyne-substituted 1,3-oxazines by reaction with arylpropynamides.

It can also be used as a coupling agent in the synthesis of block copolymers by anionic polymerization.

Malonyl Dichloride is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products.

Boiling point:	53-55 °C/19 mmHg (lit.)
Density	1.449 g/mL at 25 °C (lit.)
refractive index	n20/D 1.465(lit.)
Flash point:	117 °F
storage temp.	2-8°C
form	Liquid
pka	6.86±0.46(Predicted)
color	Clear yellow to orange to brown
Water Solubility	decomposes
BRN	774044
CAS DataBase Reference	1663-67-8(CAS DataBase Reference)
NIST Chemistry Reference	Malonyl dichloride(1663-67-8)
EPA Substance Registry System	Propanedioyl dichloride (1663-67-8)

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…