Methyl malonyl chloride

Synonym(s):Methyl chloroformylacetate;Methyl malonyl chloride

CAS NO.：37517-81-0
Empirical Formula: C4H5ClO3
Molecular Weight: 136.53
MDL number: MFCD00013657
EINECS: 253-540-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-07-27 17:31:07

What is Methyl malonyl chloride?

Chemical properties

Clear light yellow to yellow liquid

The Uses of Methyl malonyl chloride

Methyl malonyl chloride is used as pharmaceutical intermediate. Used in anti-cancer drugs.

General Description

Methyl 3-chloro-3-oxopropionate reacts with 4-cyano-1,1′-biphenyl derivatives bearing ω-hydroxyalkyl substituents to yield liquid-crystalline linear malonates and cyanoacetates.

Properties of Methyl malonyl chloride

Boiling point:	57-59 °C/12 mmHg (lit.)
Density	1.273 g/mL at 25 °C (lit.)
refractive index	n20/D 1.432(lit.)
Flash point:	176 °F
storage temp.	2-8°C
solubility	soluble in Chloroform, Ethyl Acetate
pka	9.33±0.46(Predicted)
form	Liquid
color	Colorless
Specific Gravity	1.275
Water Solubility	Reacts with water.
Sensitive	Lachrymatory
BRN	1754078
CAS DataBase Reference	37517-81-0(CAS DataBase Reference)
NIST Chemistry Reference	Methyl malonyl chloride(37517-81-0)

Safety information for Methyl malonyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.