4-Nitro-1,3-phenylenediamine

CAS NO.：5131-58-8
Empirical Formula: C6H7N3O2
Molecular Weight: 153.14
MDL number: MFCD00025289
EINECS: 225-876-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:32

What is 4-Nitro-1,3-phenylenediamine?

Chemical properties

Yellow crystal powder

The Uses of 4-Nitro-1,3-phenylenediamine

4-Nitro-1,3-diaminobenzene is a general chemical reagent used in the synthesis of pharmaceuticals. Used in the synthesis of potent and selective Chk-1 inhibitors in the treatment of various cancers.

Definition

ChEBI: 4-nitro-1,3-phenylenediamine is a C-nitro compound.

General Description

Orange prisms with blue luster or yellow crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Nitro-1,3-phenylenediamine is an amine/organonitrate. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for 4-Nitro-1,3-phenylenediamine are not available, but 4-Nitro-1,3-phenylenediamine is probably combustible.

Safety Profile

Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic vapors of NOx.

Properties of 4-Nitro-1,3-phenylenediamine

Melting point:	161°C
Boiling point:	276.04°C (rough estimate)
Density	1.3682 (rough estimate)
vapor pressure	0.007Pa at 25℃
refractive index	1.6500 (estimate)
solubility	almost transparency in hot Methanol
form	powder to crystal
Colour Index	76030
pka	0.99±0.10(Predicted)
color	Yellow compound in hair dyes
Water Solubility	<0.1 g/100 mL at 20.5 ºC
BRN	2094904
CAS DataBase Reference	5131-58-8(CAS DataBase Reference)
EPA Substance Registry System	4-Nitro-m-phenylenediamine (5131-58-8)

Safety information for 4-Nitro-1,3-phenylenediamine

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.