4-Morpholineethanesulfonic acid
Synonym(s):2-(N-Morpholino) ethanesulfonic acid;2-(N-Morpholino)ethanesulfonic Acid;4-Morpholineethanesulfonic acid
- CAS NO.:4432-31-9
- Empirical Formula: C6H13NO4S
- Molecular Weight: 195.24
- MDL number: MFCD00006181
- EINECS: 224-632-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is 4-Morpholineethanesulfonic acid?
Chemical properties
White/clear crystalline powder
The Uses of 4-Morpholineethanesulfonic acid
Biological buffer.
The Uses of 4-Morpholineethanesulfonic acid
MES solution has been used to activate microspheres. It has also been used as a component of activating solution to activate carboxyl groups of poly lactic-co-glycolic acid (PLGA).
What are the applications of Application
MES solution is used as a running buffer for resolving very small proteins
What are the applications of Application
MES is a zwitterionic buffer effective in the pH range of 6-8, used in various protein characterization assays
Definition
ChEBI: 2-(N-morpholino)ethanesulfonic acid is a Good's buffer substance, pKa = 6.15 at 20 ℃. It is an organosulfonic acid and a MES. It is a conjugate acid of a 2-(N-morpholino)ethanesulfonate. It is a tautomer of a 2-(N-morpholiniumyl)ethanesulfonate.
General Description
MES is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. It does not form complexes with majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes.
Flammability and Explosibility
Not classified
storage
Store at RT
Purification Methods
Crystallise MES from hot EtOH containing a little water. The picrate crystallises from EtOH and has m 178.8-182o. [Malkiel & Mason J Org Chem 8 199 1943, Beilstein 27 III/IV 370.]
Properties of 4-Morpholineethanesulfonic acid
Melting point: | >300 °C(lit.) |
Boiling point: | 102°C |
Density | 1.208 (estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | 2-8°C |
solubility | H2O: 0.5 M at 20 °C, clear |
pka | pKa at 0.1M ionic: 0°, 6.38; 20°, 6.15; 37°, 5.98; pKa1 1.99; pKa2 6.21; pKa/°C -0.011 |
form | Powder |
color | White |
PH | 2.5-4.0 (25℃ in neat) |
PH Range | 5.5 - 6.7 |
Water Solubility | 185.2g/L at 20℃ |
λmax | λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01 |
Merck | 13,5929 |
BRN | 6350956 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 4432-31-9(CAS DataBase Reference) |
EPA Substance Registry System | 4-Morpholineethanesulfonic acid (4432-31-9) |
Safety information for 4-Morpholineethanesulfonic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 4-Morpholineethanesulfonic acid
InChIKey | SXGZJKUKBWWHRA-UHFFFAOYSA-N |
4-Morpholineethanesulfonic acid manufacturer
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
MES Buffer CAS 4432-31-9View Details
4432-31-9 -
Mes 97% CAS 4432-31-9View Details
4432-31-9 -
2-Morpholinoethanesulfonic Acid CAS 4432-31-9View Details
4432-31-9 -
MES CAS 4432-31-9View Details
4432-31-9 -
MES solution CAS 4432-31-9View Details
4432-31-9 -
MES CAS 4432-31-9View Details
4432-31-9 -
MOPS solution CASView Details
-
MES solution CASView Details