4'-Methylbiphenyl-2-carboxylic acid

CAS NO.：7148-03-0
Empirical Formula: C14H12O2
Molecular Weight: 212.24
MDL number: MFCD00045826
EINECS: 230-462-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 4'-Methylbiphenyl-2-carboxylic acid?

Chemical properties

Light yellow solid

The Uses of 4'-Methylbiphenyl-2-carboxylic acid

4’-Methylbiphenyl-2-carboxylic Acid is used in the synthesis of angiotensin II receptor antagonists used as potent orally active antihypertensives.

General Description

4′-Methyl-2-biphenylcarboxylic acid (4′-Methyl-bi-phenyl-2-carboxyl-ic acid) can be synthesized by reacting 4′-methylbiphenyl-2-carbonitrile with methanol and 30% NaOH solution. Its crystal structure has been characterized by the centrosymmetric hydrogen-bonded dimers.

Purification Methods

Crystallise the acid from toluene or *C6H6 (m 147-148o). [Beilstein 9 H 677, 9 IV 2523.]

Properties of 4'-Methylbiphenyl-2-carboxylic acid

Melting point:	146-148°C
Boiling point:	354.5±11.0 °C(Predicted)
Density	1.156±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol
form	Solid
pka	3.90±0.36(Predicted)
color	White
CAS DataBase Reference	7148-03-0(CAS DataBase Reference)
EPA Substance Registry System	[1,1'-Biphenyl]-2-carboxylic acid, 4'-methyl- (7148-03-0)

Safety information for 4'-Methylbiphenyl-2-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.