4-Methylaniline hydrochloride

Synonym(s):4-Methylaniline hydrochloride

CAS NO.：540-23-8
Empirical Formula: C7H10ClN
Molecular Weight: 143.61
MDL number: MFCD00035497
EINECS: 208-740-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:34

4-Methylaniline hydrochloride Structural

What is 4-Methylaniline hydrochloride?

Chemical properties

white to light beige crystalline powder, crystals

The Uses of 4-Methylaniline hydrochloride

p-Toluidine Hydrochloride acts as a reagent for the preparation and biological activity of N-acylleucine (arylaminoethyl)amides as non-covalent inhibitors of cathepsin K, L and S. Catalyst in the chemistry of azasteroids.

What are the applications of Application

p-Toluidine hydrochloride is a toluene derivative for proteomics research

General Description

Off-white to grayish-white crystals.

Air & Water Reactions

Water soluble. May be sensitive to moisture.

Reactivity Profile

4-Methylaniline hydrochloride reacts with oxidizing and alkali materials. .

Fire Hazard

Flash point data for 4-Methylaniline hydrochloride are not available, but 4-Methylaniline hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also p-TOLUIDINE.

Purification Methods

Crystallise the salt from MeOH containing a few drops of conc HCl or aqueous EtOH. Dry it under vacuum over paraffin chips. [Beilstein 12 II 587, 12 III 2021, 12 IV 1869.]

Properties of 4-Methylaniline hydrochloride

Melting point:	243-245 °C(lit.)
Density	1.193 g/cm3
storage temp.	Store below +30°C.
Water Solubility	Soluble in water
solubility	DMSO (Sparingly), Methanol (Slightly)
form	powder to crystal
color	White to Gray to Red
BRN	3557540
Stability:	Hygroscopic
CAS DataBase Reference	540-23-8(CAS DataBase Reference)
EPA Substance Registry System	p-Toluidine hydrochloride (540-23-8)

Safety information for 4-Methylaniline hydrochloride

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H351:Carcinogenicity H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.