4-Methyl-3-nitrobenzoyl chloride

Synonym(s):3-Nitro-p-toluoyl chloride

CAS NO.：10397-30-5
Empirical Formula: C8H6ClNO3
Molecular Weight: 199.59
MDL number: MFCD00035747
EINECS: 233-858-1
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-30 16:20:48

4-Methyl-3-nitrobenzoyl chloride Structural

What is 4-Methyl-3-nitrobenzoyl chloride?

The Uses of 4-Methyl-3-nitrobenzoyl chloride

4-Methyl-3-nitrobenzoyl chloride was used in the synthesis of 4-amino-1,5-naphthalenedisulphonate acid monosodium salt, an intermediate employed in the synthesis of modified suramin molecule.
It may be used in the synthesis of the following:

benzophenone derivative
substituted 3-amino-4-methyl-N-phenylbenzamide
retroamide
4-methyl-3-nitro-N-phenylbenzamide

General Description

4-Methyl-3-nitrobenzoyl chloride is a benzoyl chloride derivative. It has been reported to be synthesized from 4-methyl-3-nitrobenzoic acid.

Purification Methods

Recrystallise the acid from EtOH. The S-benzylisothiuronium salt has m 167-168o (EtOH). The acid chloride [10397-30-5] has m 20-21o, b 185o/36mm, and the methyl ester [7356-11-8] crystallises as pale yellow needles from MeOH with m 51o. [Beilstein 9 H 502, 9 II 334, 9 III 2359.]

Properties of 4-Methyl-3-nitrobenzoyl chloride

Melting point:	20-21 °C(lit.)
Boiling point:	185 °C36 mm Hg(lit.)
Density	1.37 g/mL at 25 °C(lit.)
refractive index	n20/D 1.581(lit.)
Flash point:	>230 °F
CAS DataBase Reference	10397-30-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Methyl-3-nitrobenzoyl chloride(10397-30-5)

Safety information for 4-Methyl-3-nitrobenzoyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.