4-Methoxycinnamic acid

Synonym(s):trans-3-(4-Methoxyphenyl)acrylic acid

CAS NO.：830-09-1
Empirical Formula: C10H10O3
Molecular Weight: 178.18
MDL number: MFCD00004398
EINECS: 212-594-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

What is 4-Methoxycinnamic acid?

Chemical properties

white fine crystalline powde

The Uses of 4-Methoxycinnamic acid

4-Methoxycinnamic acid(p-MCA) exerted antihyperglycemic/hypoglycemic effect by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.

The Uses of 4-Methoxycinnamic acid

It exerts anti-hyperglycemic/ hypoglycemic effect by stimulating insulin secretion from pancreas. It could be developed into a new potential therapeutic agent used in type 2 diabetic patients.

Definition

ChEBI: A methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 3452, 1957 DOI: 10.1021/ja01570a037
Tetrahedron Letters, 31, p. 5913, 1990 DOI: 10.1016/S0040-4039(00)97992-9

Purification Methods

Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]

Properties of 4-Methoxycinnamic acid

Melting point:	173.5 °C(lit.)
Boiling point:	250.41°C (rough estimate)
Density	1.1479 (rough estimate)
refractive index	1.5088 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in dimethyl sulfoxide and methanol.
pka	pK1:4.539 (25°C)
form	Fine Crystalline Powder
color	White
InChI	InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)
CAS DataBase Reference	830-09-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Propenoic acid, 3-(4-methoxyphenyl)-(830-09-1)
EPA Substance Registry System	2-Propenoic acid, 3-(4-methoxyphenyl)- (830-09-1)

Safety information for 4-Methoxycinnamic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.