4-Methoxy-2-aminobenzothiazole
- CAS NO.:5464-79-9
- Empirical Formula: C8H8N2OS
- Molecular Weight: 180.23
- MDL number: MFCD00005792
- EINECS: 226-763-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-Methoxy-2-aminobenzothiazole?
Chemical properties
Beige crystalline powder
The Uses of 4-Methoxy-2-aminobenzothiazole
2-Amino-4-methoxybenzothiazole is a useful research intermediate for the synthesis of various benzothiazole and aminobenzothiazoles derivatives with antibacterial and antifungal activity.
General Description
Beige chunky solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 4-Methoxy-2-aminobenzothiazole emits very toxic fumes of NOx and SOx.
Fire Hazard
Flash point data for 4-Methoxy-2-aminobenzothiazole are not available. 4-Methoxy-2-aminobenzothiazole is probably combustible.
Biochem/physiol Actions
2-Amino-4-methoxybenzothiazole on condensation reaction with 4-acetamidobenzaldehyde affords tridentate Schiff bases. It reacts with 2,4,6-trichloro 1,3,5-triazine to give 2-(4-methoxybenzothiazol-2′-ylamino)-4-(phenylthioureido)-6-(substitutedthioureido)-1,3,5-triazines.
Properties of 4-Methoxy-2-aminobenzothiazole
Melting point: | 153-155 °C (lit.) |
Boiling point: | 240°C (rough estimate) |
Density | 1.2425 (rough estimate) |
refractive index | 1.5690 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
form | Crystalline Powder |
pka | 4.09±0.10(Predicted) |
color | Beige |
Water Solubility | <0.1 g/100 mL at 19.5 ºC |
BRN | 141363 |
CAS DataBase Reference | 5464-79-9(CAS DataBase Reference) |
EPA Substance Registry System | 2-Amino-4-methoxybenzothiazole (5464-79-9) |
Safety information for 4-Methoxy-2-aminobenzothiazole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for 4-Methoxy-2-aminobenzothiazole
InChIKey | YEBCRAVYUWNFQT-UHFFFAOYSA-N |
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin F (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin E Tubulysin G Tubulysin C (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-Chloro-3-(chloromethyl)pyridine 2-(4-Bromopyridin-2-yl)acetonitrile Diethyl 2,5-di(furan-2-yl)terephthalate 5-Aminophthalazine 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (4-(1-Hydroxycyclobutyl)phenyl)boronic acid pinacol ester Ethyl (2Z)-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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