4'-HYDROXYCHALCONE
- CAS NO.:2657-25-2
- Empirical Formula: C15H12O2
- Molecular Weight: 224.25
- MDL number: MFCD00016484
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 18:00:59
What is 4'-HYDROXYCHALCONE?
Description
4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.
Chemical properties
yellow-cream powder
The Uses of 4'-HYDROXYCHALCONE
antineoplastic,
The Uses of 4'-HYDROXYCHALCONE
4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).
Definition
ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.
Properties of 4'-HYDROXYCHALCONE
Melting point: | 174-178 °C |
Boiling point: | 419.6±45.0 °C(Predicted) |
Density | 1.191±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml |
pka | 7.72±0.15(Predicted) |
form | powder to crystal |
color | Light orange to Yellow to Green |
BRN | 2049150 |
CAS DataBase Reference | 2657-25-2(CAS DataBase Reference) |
Safety information for 4'-HYDROXYCHALCONE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4'-HYDROXYCHALCONE
InChIKey | UAHGNXFYLAJDIN-IZZDOVSWSA-N |
Abamectin manufacturer
CHROMOSYNTH PVT LTD
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