MORIN
Synonym(s):2′,3,4′,5,7-Pentahydroxyflavone
- CAS NO.:480-16-0
- Empirical Formula: C15H10O7
- Molecular Weight: 302.24
- MDL number: MFCD00006826
- EINECS: 207-542-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 13:37:16
What is MORIN?
Chemical properties
yellow to brown powder
The Uses of MORIN
Morin is a natural pentahydroxyflavonol with antioxidant activity. It reduces CD36 expression and oxLDL uptake in U937-derived macrophages, inhibits PIM-1 kinase in vitro (IC50 = 2.7 μM), and reduces the activity of cytochrome P450 isoform 3A4 in liver microsomes. Through these and other actions, morin has anti-oxidant, anti-inflammatory, and other actions in animal models.[Cayman Chemical]
The Uses of MORIN
P450 and ATPase inhibitor
The Uses of MORIN
Morin is a polyphenolic flavonoid with radical scavenging ability. In addition it maintains the potential for suppression of lipopolysaccharide-induced neuroinflammation.
What are the applications of Application
Morin anhydrous is an antioxidant flavonoid
Definition
ChEBI: A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.
Safety Profile
Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Stir morin at room temperature with ten times its weight of absolute EtOH, then leave overnight to settle. Filter it off, and evaporate under a heat lamp to one-tenth its volume. An equal volume of water is added, and the precipitated morin is filtered off, dissolved in the minimum amount of EtOH and again precipitated with an equal volume of water. The precipitate is filtered off, washed with water and dried at 110o for 1hour (yield ca 2.5%.). [Perkins & Kalkwarf Anal Chem 28 1989 1956.] It complexes with W and Zr. [Beilstein 18 H 239, 18 III/IV 3468, 18/5 V 492.]
Properties of MORIN
Melting point: | 299-300 °C (dec.)(lit.) |
Boiling point: | 363.28°C (rough estimate) |
Density | 1.3616 (rough estimate) |
refractive index | 1.4790 (estimate) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | methanol: 50 mg/mL |
form | powder |
Colour Index | 75660 |
pka | 6.30±0.40(Predicted) |
color | yellow |
Water Solubility | 0.25g/L(20 ºC) |
Merck | 6269 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 480-16-0(CAS DataBase Reference) |
EPA Substance Registry System | Morin (480-16-0) |
Safety information for MORIN
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for MORIN
InChIKey | YXOLAZRVSSWPPT-UHFFFAOYSA-N |
MORIN manufacturer
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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