4-Hydroxybenzophenone
Synonym(s):4-Hydroxybenzophenone;p-Benzoylphenol
- CAS NO.:1137-42-4
- Empirical Formula: C13H10O2
- Molecular Weight: 198.22
- MDL number: MFCD00002355
- EINECS: 214-507-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 20:21:46
What is 4-Hydroxybenzophenone?
Chemical properties
white to beige fine crystalline powder
The Uses of 4-Hydroxybenzophenone
4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.
The Uses of 4-Hydroxybenzophenone
Metabolite of benzophenone.
Preparation
Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.
Definition
ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0
Flammability and Explosibility
Not classified
Purification Methods
Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]
Properties of 4-Hydroxybenzophenone
Melting point: | 132-135 °C(lit.) |
Boiling point: | 260-262°C 42mm |
Density | 1.1184 (rough estimate) |
vapor pressure | 0Pa at 20℃ |
refractive index | 1.5954 (estimate) |
Flash point: | 260-262°C/24mm |
storage temp. | Store below +30°C. |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | 8.14±0.13(Predicted) |
form | Powder |
color | White to beige to brown |
Water Solubility | Insoluble in water. |
BRN | 777776 |
CAS DataBase Reference | 1137-42-4(CAS DataBase Reference) |
NIST Chemistry Reference | Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4) |
EPA Substance Registry System | Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4) |
Safety information for 4-Hydroxybenzophenone
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P314:Get medical advice/attention if you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-Hydroxybenzophenone
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