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HomeProduct name list4-Hydroxybenzophenone

4-Hydroxybenzophenone

Synonym(s):4-Hydroxybenzophenone;p-Benzoylphenol

  • CAS NO.:1137-42-4
  • Empirical Formula: C13H10O2
  • Molecular Weight: 198.22
  • MDL number: MFCD00002355
  • EINECS: 214-507-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 20:21:46
4-Hydroxybenzophenone Structural

What is 4-Hydroxybenzophenone?

Chemical properties

white to beige fine crystalline powder

The Uses of 4-Hydroxybenzophenone

4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.

The Uses of 4-Hydroxybenzophenone

Metabolite of benzophenone.

Preparation

Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.

Definition

ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0

Flammability and Explosibility

Not classified

Purification Methods

Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]

Properties of 4-Hydroxybenzophenone

Melting point: 132-135 °C(lit.)
Boiling point: 260-262°C 42mm
Density  1.1184 (rough estimate)
vapor pressure  0Pa at 20℃
refractive index  1.5954 (estimate)
Flash point: 260-262°C/24mm
storage temp.  Store below +30°C.
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 8.14±0.13(Predicted)
form  Powder
color  White to beige to brown
Water Solubility  Insoluble in water.
BRN  777776
CAS DataBase Reference 1137-42-4(CAS DataBase Reference)
NIST Chemistry Reference Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4)
EPA Substance Registry System Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4)

Safety information for 4-Hydroxybenzophenone

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H373:Specific target organ toxicity, repeated exposure
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P273:Avoid release to the environment.
P314:Get medical advice/attention if you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for 4-Hydroxybenzophenone

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