4-FLUOROPHENYLMAGNESIUM BROMIDE
- CAS NO.：352-13-6
- Empirical Formula: C6H4BrFMg
- Molecular Weight: 199.3
- MDL number: MFCD00009667
- EINECS: 627-087-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4-FLUOROPHENYLMAGNESIUM BROMIDE?
Chemical properties
clear yellow to red-brown solution
The Uses of 4-FLUOROPHENYLMAGNESIUM BROMIDE
4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.
The Uses of 4-FLUOROPHENYLMAGNESIUM BROMIDE
4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:
- Useful key intermediate in the synthesis of paroxetine.
- Arylsulfides via cross-coupling reaction with thiols.
- 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
- Grignard intermediate for preparing aprepitant.
Properties of 4-FLUOROPHENYLMAGNESIUM BROMIDE
| Melting point: | 5 °C |
| Boiling point: | 66°C |
| Density | 1.043 g/mL at 25 °C |
| Flash point: | −40 °F |
| storage temp. | Flammables + water-Freezer (-20°C)e area |
| form | Solution |
| color | Clear yellow to red-brown |
| Water Solubility | It reacts violently with water. |
| Sensitive | Air & Moisture Sensitive |
| BRN | 636802 |
| CAS DataBase Reference | 352-13-6 |
| EPA Substance Registry System | Magnesium, bromo(4-fluorophenyl)- (352-13-6) |
Safety information for 4-FLUOROPHENYLMAGNESIUM BROMIDE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H225:Flammable liquids H302:Acute toxicity,oral H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H371:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-FLUOROPHENYLMAGNESIUM BROMIDE
| InChIKey | QYBFFRXNNFXREA-UHFFFAOYSA-M |
Abamectin manufacturer
Sanpra Synthesis Private Limited
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Phone:+91-9246161600
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product: 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF
REDDY N REDDY PHARMACEUTICALS
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Phone:+91-9848096759
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product: 352-13-6 98%
JSK Chemicals
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Phone:+919879767970
Whatsapp: +91 9879767970
product: 4-Fluorophenylmagnesium bromide 1.0 99%
Wellchem Laboratories
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Phone:+91-9892737187
Whatsapp: +91-9892737187
product: (4-Fluorophenyl)-magnesium bromide 99%
HYCHEM LABORATORIES
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Phone:+91-9391007257
Whatsapp: +91-9391007257
product: 4-Fluorophenyl Magnesium Bromide (2.0 M in Diethyl Ether)
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