4-Ethynylanisole
Synonym(s):1-Ethynyl-4-methoxybenzene
- CAS NO.:768-60-5
- Empirical Formula: C9H8O
- Molecular Weight: 132.16
- MDL number: MFCD00168815
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 10:25:49
What is 4-Ethynylanisole?
Chemical properties
Pale Yellow Oil
The Uses of 4-Ethynylanisole
4-Ethynylanisole was used in the synthesis of photo luminescent 1,2-dihydrophosphinines via a [4 + 2] cycloaddition. Along with an arylboronic acid and sodium azide in a copper-catalyzed, three-component synthesis of trisubstituted 1,2,4-triazoles. In a study of a gold (III)-catalyzed hydroamination of alkynes leading to N-vinylindoles3.
The Uses of 4-Ethynylanisole
Intermediate in the synthesis of histamine H3-receptor antagonists. Also utilized to prepare its luminescent copper complex
The Uses of 4-Ethynylanisole
Intermediates of Liquid Crystals
The Uses of 4-Ethynylanisole
1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.1
Definition
ChEBI: 1-Eth-1-ynyl-4-methoxybenzene is a member of methoxybenzenes.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 9, p. 230, 1998
Synthesis, p. 305, 1978
Tetrahedron, 62, p. 6673, 2006 DOI: 10.1016/j.tet.2005.12.077
General Description
4-Ethynylanisole forms the corresponding propargyl aldehyde in good yield directly from DMF-dimethyl acetal without the need for making an acetylide salt. 1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.
Properties of 4-Ethynylanisole
Melting point: | 28-29 °C (lit.) |
Boiling point: | 87-91 °C/11 mmHg (lit.) |
Density | 1.019 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 180 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Acetontrile (Slightly), Chloroform (Slightly) |
form | Liquid or Low Melting Solid |
color | Clear colorless to deep yellow or brown |
Water Solubility | Insoluble in water. Soluble in chloroform, acetone, dichloromethane, and methanol. |
Sensitive | Light Sensitive |
Stability: | Light and Temperature Sensitive |
CAS DataBase Reference | 768-60-5(CAS DataBase Reference) |
NIST Chemistry Reference | 4-CH3O-C6H4-CCH(768-60-5) |
Safety information for 4-Ethynylanisole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Ethynylanisole
InChIKey | KBIAVTUACPKPFJ-UHFFFAOYSA-N |
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