4-Chlorophenylboronic acid

Chemical properties

off-white to beige crystalline powder

Chemical properties

4-Chlorophenylboronic acid is white or off-white crystalline powder. It has certain solubility in water and is soluble in strong polar organic solvents such as dimethyl sulfoxide, but insoluble in ether solvents. It has similar chemical properties to phenylboronic acid.

The Uses of 4-Chlorophenylboronic acid

4-Chlorophenylboronic acid can be used as a reactant in:

• Palladium-catalyzed direct arylation.
• Cyclopalladation.
• Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation.
• Copper-mediated ligandless aerobic fluoroalkylation.
• Pd-catalyzed arylative cyclization.
• Ruthenium catalyzed direct arylation.
• Ligand-free copper-catalyzed coupling reactions.
• Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions.

• Substituted diarylmethylidenefluorenes via Suzuki coupling reaction.
• Baclofen lactam by Suzuki coupling of a pyrrolinyl tosylate, followed by hydrogenation reaction.
• Palladium(II) thiocarboxamide complexes as Suzuki coupling catalysts.
• Biaryls by Suzuki reactions of aryl chlorides, bromides, and iodides with arylboronic acids.

The Uses of 4-Chlorophenylboronic acid

4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones.

What are the applications of Application

4-Chlorophenylboronic acid is a useful reagent for Suzuki couple reactions