Phenylboronic acid

Description

Phenylboronic acid, or benzeneboronic acid, is prepared by the reaction of the Grignard reagent PhMgBr with B(OMe)3. It and its aryl-substituted derivatives are commonly used as building blocks in synthetic organic chemistry—most often in the Suzuki coupling reaction, in which a boronic acid reacts with an organic halide to form a carbon–carbon bond. Boronic acids’ reactions with 1,2- and 1,3-diols are useful for saccharide recognition.

The Uses of Phenylboronic acid

Phenylboronic Acid is a compound used in organic synthesis of various pharmaceutical goods.
Phenylboronic acid (PBA) and its derivatives can bind sugars and other diol compounds to form cyclic boronate esters. These esters bear negative charges. Due to this reaction, sugars can be detected by means of electrochemical and optical techniques.
PBA modified electrodes have been constructed as reagentless electrochemical sensors. There, PBA is absorbed on the electrode surface either as a self- assembled monolayer film ore a polymer thin film. Basically, for optical detection techniques for the detection of sugars, PBA is modified with a chromophore that should change its properties on reaction with a sugar.

Reaction of Phenylboronic acid with a sugar

What are the applications of Application

Phenylboronic acid is used in organic synthesis cross coupling reactions