4'-Chloroacetoacetanilide

CAS NO.：101-92-8
Empirical Formula: C10H10ClNO2
Molecular Weight: 211.64
MDL number: MFCD00000613
EINECS: 202-989-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

What is 4'-Chloroacetoacetanilide?

Chemical properties

off-white to beige crystalline powder

The Uses of 4'-Chloroacetoacetanilide

4′-Chloroacetoacetanilide was used in recombinant androgen receptor competitive binding assay for analysis of natural, synthetic and environmental chemicals.

Definition

ChEBI: P-Chloroacetoacetanilide is an anilide.

General Description

4′-Chloroacetoacetanilide was trilithiated with lithium diisopropylamide and condensed with several aromatic esters, followed by neutralization, separate acid cyclization and rearrangements to yield 4-anilino-6-aryl-2H-pyran-2-ones. It undergoes three-component reaction with a mixture of aromatic aldehyde and 5-aminotetrazole to form N,7-diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide.

Safety Profile

Moderately toxic by intraperitonealroute. Combustible whenexposed to heat or flame. Dangerous: see ANILINE andCYANIDE. Can react vigorously with oxidizing materials.To fight fire, use water, foam, CO2, water mist, drychemical. When heated to decompo

Properties of 4'-Chloroacetoacetanilide

Melting point:	131-134 °C (lit.)
Boiling point:	303°C (rough estimate)
Density	1.44 g/cm3 (20℃)
vapor density	7.31
refractive index	1.5388 (estimate)
Flash point:	350°F(COC)
storage temp.	Inert atmosphere,Room Temperature
solubility	acetone: soluble25mg/mL, clear, colorless to light yellow
pka	11.00±0.46(Predicted)
form	Crystalline Powder
color	Off-white to beige
CAS DataBase Reference	101-92-8(CAS DataBase Reference)
NIST Chemistry Reference	Butanamide, N-(4-chlorophenyl)-3-oxo-(101-92-8)
EPA Substance Registry System	Butanamide, N-(4-chlorophenyl)-3-oxo- (101-92-8)

Safety information for 4'-Chloroacetoacetanilide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.