4'-Methoxyacetoacetanilide
- CAS NO.：5437-98-9
- Empirical Formula: C11H13NO3
- Molecular Weight: 207.23
- MDL number: MFCD00008783
- EINECS: 226-615-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 4'-Methoxyacetoacetanilide?
Chemical properties
WHITE TO VERY SLIGHTLY YELLOW POWDER
The Uses of 4'-Methoxyacetoacetanilide
N-(4-Methoxyphenyl)-3-oxobutanamide is an intermediate in the synthesis of Tafenoquine-d3 Succinate is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
Synthesis Reference(s)
The Journal of Organic Chemistry, 11, p. 803, 1946 DOI: 10.1021/jo01176a024
Properties of 4'-Methoxyacetoacetanilide
| Melting point: | 115-118 °C |
| Boiling point: | 346.25°C (rough estimate) |
| Density | 1.1878 (rough estimate) |
| vapor pressure | 0.001Pa at 20℃ |
| refractive index | 1.5100 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | 11.35±0.46(Predicted) |
| color | White to Blue |
| Water Solubility | soluble |
| CAS DataBase Reference | 5437-98-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Butanamide, 3-oxo-n-(4-methoxyphenyl)-(5437-98-9) |
| EPA Substance Registry System | Butanamide, N-(4-methoxyphenyl)-3-oxo- (5437-98-9) |
Safety information for 4'-Methoxyacetoacetanilide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for 4'-Methoxyacetoacetanilide
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