183322-18-1
Product Name:
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
Formula:
C14H17ClN2O4
Synonyms:
4-Chloro-6,7-bis(2-methoxyethoxy)-quinazoline;PF-508367
Inquiry
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 312.75 g/mol |
|---|---|
| XLogP3 | 2.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 8 |
| Exact Mass | 312.0876847 g/mol |
| Monoisotopic Mass | 312.0876847 g/mol |
| Topological Polar Surface Area | 62.7 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 298 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
Description
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate; has been used as a precursor in the synthesis of inhibitors, dual RTK and HDAC inhibitors, and anticancer compounds; a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib, with antiproliferative activity.
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