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HomeProduct name list4-Bromopyrazole

4-Bromopyrazole

4-Bromopyrazole Structural

What is 4-Bromopyrazole?

Chemical properties

White to cream crystalline powder

The Uses of 4-Bromopyrazole

4-Bromopyrazole is a monosubstituted pyrazole compound used as a starting material for the synthesis of 1,4′-biazoles and the Suzuki reaction. It is also used as an inhibitor of human liver alcohol dehydrogenase and in mutagenicity studies in the Salmonella typhimurium L-arabinose resistance test.

What are the applications of Application

4-Bromopyrazole is a starting material employed in a synthesis of 1,4′-bipyrazoles

General Description

4-Bromopyrazole is a pyrazole derivative. It is reported to react with titanium tetrachloride to afford binary adducts. Mutagenicity of 4-bromopyrazole has been tested using the L-arabinose forward mutation assay of Salmonella typhimurium. It is reported to inhibit the oxidative phosphorylation, the ATP-32P exchange reaction, and energy dependent and independent calcium uptake.

Properties of 4-Bromopyrazole

Melting point: 93-96 °C (lit.)
Boiling point: 250-260 °C (lit.)
Density  1.5979 (rough estimate)
refractive index  1.5260 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform, DMSO, Methanol
pka 12.71±0.50(Predicted)
form  Crystalline Powder
color  White to cream
Water Solubility  Slightly soluble in water.
CAS DataBase Reference 2075-45-8(CAS DataBase Reference)
NIST Chemistry Reference 1H-pyrazole, 4-bromo-(2075-45-8)

Safety information for 4-Bromopyrazole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-Bromopyrazole

InChIKey FHZALEJIENDROK-UHFFFAOYSA-N

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