Mestinon
Synonym(s):3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide;Pyridostigmine bromide
- CAS NO.:101-26-8
- Empirical Formula: C9H13BrN2O2
- Molecular Weight: 261.12
- MDL number: MFCD00079283
- EINECS: 202-929-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is Mestinon?
Description
Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Chemical properties
White Solid
The Uses of Mestinon
Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.
What are the applications of Application
Pyridostigmine bromide is An inhibitor of ACE (acetylcholinesterase)
Definition
ChEBI: Pyridostigmine bromide is a pyridinium salt.
brand name
Mestinon (Valeant); Regonol (Sandoz).
General Description
Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.
Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.
Biochem/physiol Actions
Acetylcholinesterase inhibitor.
Clinical Use
Myasthenia gravis
Drug interactions
Potentially hazardous interactions with other drugs
Aminoglycosides, clindamycin and polymyxins
antagonise effects of pyridostigmine.
Metabolism
Pyridostigmine undergoes hydrolysis by cholinesterases and is also metabolised in the liver. It appears that 75% of the plasma clearance of pyridostigmine depends on renal function. 3-Hydroxy-N-methylpyridinium has been identified as one of the 3 metabolites isolated from the urine. Pyridostigmine is excreted mainly in the urine as unchanged drug and metabolites.
Properties of Mestinon
Melting point: | 154 °C |
storage temp. | 2-8°C |
solubility | Very soluble in water and in ethanol (96 per cent). |
form | neat |
form | Solid |
color | White to Almost white |
Merck | 14,7977 |
CAS DataBase Reference | 101-26-8(CAS DataBase Reference) |
EPA Substance Registry System | Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8) |
Safety information for Mestinon
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H317:Sensitisation, Skin |
Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Mestinon
InChIKey | VNYBTNPBYXSMOO-UHFFFAOYSA-M |
Abamectin manufacturer
PANCHSHEEL ORGANICS LTD
Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd)
Sami Sabinsa Group Limited (formerly Sami Labs Limited)
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