4-Bromomethyl-7-methoxycoumarin

Synonym(s):BMC;Br-Mmc

CAS NO.：35231-44-8
Empirical Formula: C11H9BrO3
Molecular Weight: 269.09
MDL number: MFCD00006869
EINECS: 252-448-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

4-Bromomethyl-7-methoxycoumarin Structural

What is 4-Bromomethyl-7-methoxycoumarin?

Chemical properties

Light Green-Yellow Crystals

The Uses of 4-Bromomethyl-7-methoxycoumarin

4-Bromomethyl-7-methoxycoumarin can be used as fluorescent label for fatty acids. For derivatization, TLC and HPLC separation, and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2.

The Uses of 4-Bromomethyl-7-methoxycoumarin

4-Bromomethyl-7-methoxycoumarin has been used:

as derivatization reagent in determination of 5-fluorouracil (5-FU) in human plasma by HPLC-tandem mass spectrometry
as derivatization reagent in fluorescence detection of sodium monofluoroacetate (MFA-Na) in biological samples by HPLC
in the synthesis of new caged derivatives of hydrolysis-resistant 8-bromoadenosine cyclic 3′,5′-monophosphate (8-Br-cAMP) and 8-bromoguanosine cyclic 3′,5′-monophosphate (8-Br-cGMP)
in TLC and HPLC separation and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B₂

What are the applications of Application

4-Bromomethyl-7-methoxycoumarin is a fluorescent label for fatty acids used in conjunction with TLC and HPLC

Purification Methods

The coumarin crystallises from boiling AcOH; the crystals are washed with AcOH, EtOH and dried in a vacuum; 1HNMR (TFA) 3.97s, 4.57s, 6.62s, 6.92-7.19m and 7.80d. [Secrist et al. Biochem Biophys Res Commun 45 1262 1971, Dünges Anal Chem 49 442 1977, Beilstein 18 III/IV 348.]

Properties of 4-Bromomethyl-7-methoxycoumarin

Melting point:	213-215 °C (lit.)
Boiling point:	385.3±42.0 °C(Predicted)
Density	1.552±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	chloroform: soluble20mg/mL, clear, colorless to faintly yellow
form	Powder and/or Chunks
color	Off-white to light yellow or beige
Water Solubility	insoluble
λmax	330 nm (MeOH)
BRN	187211
Stability:	Stable, but moisture and light-sensitive. Combustible. Incompatible with strong oxidizing agents.
Major Application	Detection of nitrated explosives; measuring ultraviolet ray power; photoacid generators; polyurethane foams; photoresists silica nanoparticles
Biological Applications	Analyzing/detecting carboxylic acids;analyzing/labeling fatty acids; detecting nitric oxide; detecting/separating bile acids; labeling pyrimidine nucleobases; anticancer agents; biomedical trace analysis; herbicides; as a substrate for measuring histone acetyltransferases (HATs) activity, peptidases activity, sirtuin activity
CAS DataBase Reference	35231-44-8(CAS DataBase Reference)

Safety information for 4-Bromomethyl-7-methoxycoumarin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.