4-Bromomethyl-7-methoxycoumarin
Synonym(s):BMC;Br-Mmc
- CAS NO.：35231-44-8
- Empirical Formula: C11H9BrO3
- Molecular Weight: 269.09
- MDL number: MFCD00006869
- EINECS: 252-448-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is 4-Bromomethyl-7-methoxycoumarin?
Chemical properties
Light Green-Yellow Crystals
The Uses of 4-Bromomethyl-7-methoxycoumarin
4-Bromomethyl-7-methoxycoumarin can be used as fluorescent label for fatty acids. For derivatization, TLC and HPLC separation, and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2.
The Uses of 4-Bromomethyl-7-methoxycoumarin
4-Bromomethyl-7-methoxycoumarin has been used:
- as derivatization reagent in determination of 5-fluorouracil (5-FU) in human plasma by HPLC-tandem mass spectrometry
- as derivatization reagent in fluorescence detection of sodium monofluoroacetate (MFA-Na) in biological samples by HPLC
- in the synthesis of new caged derivatives of hydrolysis-resistant 8-bromoadenosine cyclic 3′,5′-monophosphate (8-Br-cAMP) and 8-bromoguanosine cyclic 3′,5′-monophosphate (8-Br-cGMP)
- in TLC and HPLC separation and fluorometric analysis of a wide range of naturally occurring acids, including bile and thromboxane B2
What are the applications of Application
4-Bromomethyl-7-methoxycoumarin is a fluorescent label for fatty acids used in conjunction with TLC and HPLC
Purification Methods
The coumarin crystallises from boiling AcOH; the crystals are washed with AcOH, EtOH and dried in a vacuum; 1HNMR (TFA) 3.97s, 4.57s, 6.62s, 6.92-7.19m and 7.80d. [Secrist et al. Biochem Biophys Res Commun 45 1262 1971, Dünges Anal Chem 49 442 1977, Beilstein 18 III/IV 348.]
Properties of 4-Bromomethyl-7-methoxycoumarin
| Melting point: | 213-215 °C (lit.) |
| Boiling point: | 385.3±42.0 °C(Predicted) |
| Density | 1.552±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | chloroform: soluble20mg/mL, clear, colorless to faintly yellow |
| form | Powder and/or Chunks |
| color | Off-white to light yellow or beige |
| Water Solubility | insoluble |
| λmax | 330 nm (MeOH) |
| BRN | 187211 |
| Stability: | Stable, but moisture and light-sensitive. Combustible. Incompatible with strong oxidizing agents. |
| Major Application | Detection of nitrated
explosives; measuring ultraviolet ray power;
photoacid generators; polyurethane foams;
photoresists silica nanoparticles |
| Biological Applications | Analyzing/detecting
carboxylic acids;analyzing/labeling fatty acids;
detecting nitric oxide; detecting/separating bile
acids; labeling pyrimidine nucleobases;
anticancer agents; biomedical trace analysis;
herbicides; as a substrate for measuring
histone acetyltransferases (HATs) activity, peptidases
activity, sirtuin activity |
| CAS DataBase Reference | 35231-44-8(CAS DataBase Reference) |
Safety information for 4-Bromomethyl-7-methoxycoumarin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Bromomethyl-7-methoxycoumarin
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